Exercise attenuates matrix metalloproteinase activity in preexisting atherosclerotic plaque

Soo Min Shon, Jong Ho Park, Matthias Nahrendorf, Dawid Schellingerhout, Jeong Yeon Kim, Byeong Teck Kang, Sang Wuk Jeong, Eo Jin Kim, Ju Hee Ryu, Kwang Meyung Kim, Ick Chan Kwon, Dong Kun Lee, Myoung Mook Lee, Dong Eog Kim

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: Few studies have investigated if exercise by itself has anti-atherosclerotic effects, without combining interventions with a low-fat diet. We studied the effects of exercise as a stand-alone intervention on preexisting atheromata by measuring not only plaque size but also the levels of plaque-destabilizing matrix-metalloproteinase (MMP) activity in vivo. Methods and results: We used near-infrared fluorescent (NIRF) molecular imaging with an MMP-2/9 activatable NIRF probe to visualize the inflammatory protease activity within preexisting atheromata of 17-week-old ApoE-/- mice on: (a) normal chow diet (NCD), (b) Western diet (WD), and (c) WD with treadmill exercise for 10 weeks. We also measured tissue levels of aortic lipid peroxidation (LPO) and plasma levels of glucose/lipid/cytokine profiles. Exercise did not attenuate growth of preexisting atheromatous plaques. However, exercise strongly decreased proteolytic activity in plaques for animals on WD, with levels decreasing almost to NCD levels. Exercise was associated with decreased aortic LPO levels and increased blood adiponectin/leptin levels; however, exercise did not affect WD-consumption/weight-gain or improve blood glucose/lipid profiles. Conclusions: Exercise training reduced aortic MMP activity in mice with preexisting atheromata, even though they remained on a high fat diet and plaque-growth was not attenuated.

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalAtherosclerosis
Volume216
Issue number1
DOIs
Publication statusPublished - 2011 May 1
Externally publishedYes

Fingerprint

Atherosclerotic Plaques
Matrix Metalloproteinases
Lipid Peroxidation
Diet
Lipids
Fat-Restricted Diet
Molecular Imaging
Matrix Metalloproteinase 2
Adiponectin
Matrix Metalloproteinase 9
High Fat Diet
Apolipoproteins E
Growth
Leptin
Fluorescent Dyes
Weight Gain
Blood Glucose
Peptide Hydrolases
Exercise
Cytokines

Keywords

  • Atherosclerosis
  • Exercise
  • Matrix metalloproteinase
  • Molecular imaging
  • Preexisting plaque

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Shon, S. M., Park, J. H., Nahrendorf, M., Schellingerhout, D., Kim, J. Y., Kang, B. T., ... Kim, D. E. (2011). Exercise attenuates matrix metalloproteinase activity in preexisting atherosclerotic plaque. Atherosclerosis, 216(1), 67-73. https://doi.org/10.1016/j.atherosclerosis.2011.01.036

Exercise attenuates matrix metalloproteinase activity in preexisting atherosclerotic plaque. / Shon, Soo Min; Park, Jong Ho; Nahrendorf, Matthias; Schellingerhout, Dawid; Kim, Jeong Yeon; Kang, Byeong Teck; Jeong, Sang Wuk; Kim, Eo Jin; Ryu, Ju Hee; Kim, Kwang Meyung; Kwon, Ick Chan; Lee, Dong Kun; Lee, Myoung Mook; Kim, Dong Eog.

In: Atherosclerosis, Vol. 216, No. 1, 01.05.2011, p. 67-73.

Research output: Contribution to journalArticle

Shon, SM, Park, JH, Nahrendorf, M, Schellingerhout, D, Kim, JY, Kang, BT, Jeong, SW, Kim, EJ, Ryu, JH, Kim, KM, Kwon, IC, Lee, DK, Lee, MM & Kim, DE 2011, 'Exercise attenuates matrix metalloproteinase activity in preexisting atherosclerotic plaque', Atherosclerosis, vol. 216, no. 1, pp. 67-73. https://doi.org/10.1016/j.atherosclerosis.2011.01.036
Shon, Soo Min ; Park, Jong Ho ; Nahrendorf, Matthias ; Schellingerhout, Dawid ; Kim, Jeong Yeon ; Kang, Byeong Teck ; Jeong, Sang Wuk ; Kim, Eo Jin ; Ryu, Ju Hee ; Kim, Kwang Meyung ; Kwon, Ick Chan ; Lee, Dong Kun ; Lee, Myoung Mook ; Kim, Dong Eog. / Exercise attenuates matrix metalloproteinase activity in preexisting atherosclerotic plaque. In: Atherosclerosis. 2011 ; Vol. 216, No. 1. pp. 67-73.
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