Exertional Desaturation as a Predictor of Rapid Lung Function Decline in COPD

Changhwan Kim, Joon Beom Seo, Sang Min Lee, Jae Seung Lee, Jin Won Huh, Jin Hwa Lee, Seung Won Ra, Ji Hyun Lee, Eun Kyung Kim, Tae Hyung Kim, Woo Jin Kim, Sang Min Lee, Sang Yeub Lee, Seong Yong Lim, Tae Rim Shin, Ho Il Yoon, Seung Soo Sheen, Yeon Mok Oh, Yong Bum Park, Sang Do Lee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: To date, no clinical parameter has been associated with the decline in lung function other than emphysema severity in COPD. Objectives: The main purpose of this study was to explore whether the rate of lung function decline differs between COPD patients with and without exertional desaturation. Methods: A total of 224 subjects were selected from the Korean Obstructive Lung Disease cohort. Exertional desaturation was assessed using the 6-min walk test (6MWT), and defined as a post-exercise oxygen saturation (SpO2) of <90% or a ≥4% decrease. The cohort was divided into desaturator (n = 47) and non-desaturator (n = 177) groups. Results: There was a significant difference between the desaturator and non-desaturator groups in terms of the change in pre-bronchodilator forced expiratory volume in 1 s (FEV1) over a 3-year period of follow-up (p = 0.006). The mean rate of decline in FEV1 was greater in the desaturator group (33.8 ml/year) than in the non-desaturator group (11.6 ml/year). A statistically significant difference was also observed between the two groups in terms of the change in the St. George's Respiratory Questionnaire (SGRQ) total score over 3 years (p = 0.001). Conclusions: This study suggests, for the first time, that exertional desaturation may be a predictor of rapid decline in lung function in patients with COPD. The 6MWT may be a useful test to predict a rapid lung function decline in COPD.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalRespiration
Volume86
Issue number2
DOIs
Publication statusPublished - 2013 Aug 1

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Chronic Obstructive Pulmonary Disease
Lung
Forced Expiratory Volume
Obstructive Lung Diseases
Bronchodilator Agents
Emphysema
Exercise
Oxygen
Walk Test

Keywords

  • Chronic obstructive pulmonary disease
  • Computed tomography
  • Emphysema
  • Exertional desaturation
  • Lung function

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Kim, C., Seo, J. B., Lee, S. M., Lee, J. S., Huh, J. W., Lee, J. H., ... Lee, S. D. (2013). Exertional Desaturation as a Predictor of Rapid Lung Function Decline in COPD. Respiration, 86(2), 109-116. https://doi.org/10.1159/000342891

Exertional Desaturation as a Predictor of Rapid Lung Function Decline in COPD. / Kim, Changhwan; Seo, Joon Beom; Lee, Sang Min; Lee, Jae Seung; Huh, Jin Won; Lee, Jin Hwa; Ra, Seung Won; Lee, Ji Hyun; Kim, Eun Kyung; Kim, Tae Hyung; Kim, Woo Jin; Lee, Sang Min; Lee, Sang Yeub; Lim, Seong Yong; Shin, Tae Rim; Yoon, Ho Il; Sheen, Seung Soo; Oh, Yeon Mok; Park, Yong Bum; Lee, Sang Do.

In: Respiration, Vol. 86, No. 2, 01.08.2013, p. 109-116.

Research output: Contribution to journalArticle

Kim, C, Seo, JB, Lee, SM, Lee, JS, Huh, JW, Lee, JH, Ra, SW, Lee, JH, Kim, EK, Kim, TH, Kim, WJ, Lee, SM, Lee, SY, Lim, SY, Shin, TR, Yoon, HI, Sheen, SS, Oh, YM, Park, YB & Lee, SD 2013, 'Exertional Desaturation as a Predictor of Rapid Lung Function Decline in COPD', Respiration, vol. 86, no. 2, pp. 109-116. https://doi.org/10.1159/000342891
Kim C, Seo JB, Lee SM, Lee JS, Huh JW, Lee JH et al. Exertional Desaturation as a Predictor of Rapid Lung Function Decline in COPD. Respiration. 2013 Aug 1;86(2):109-116. https://doi.org/10.1159/000342891
Kim, Changhwan ; Seo, Joon Beom ; Lee, Sang Min ; Lee, Jae Seung ; Huh, Jin Won ; Lee, Jin Hwa ; Ra, Seung Won ; Lee, Ji Hyun ; Kim, Eun Kyung ; Kim, Tae Hyung ; Kim, Woo Jin ; Lee, Sang Min ; Lee, Sang Yeub ; Lim, Seong Yong ; Shin, Tae Rim ; Yoon, Ho Il ; Sheen, Seung Soo ; Oh, Yeon Mok ; Park, Yong Bum ; Lee, Sang Do. / Exertional Desaturation as a Predictor of Rapid Lung Function Decline in COPD. In: Respiration. 2013 ; Vol. 86, No. 2. pp. 109-116.
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AU - Seo, Joon Beom

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AU - Lee, Jae Seung

AU - Huh, Jin Won

AU - Lee, Jin Hwa

AU - Ra, Seung Won

AU - Lee, Ji Hyun

AU - Kim, Eun Kyung

AU - Kim, Tae Hyung

AU - Kim, Woo Jin

AU - Lee, Sang Min

AU - Lee, Sang Yeub

AU - Lim, Seong Yong

AU - Shin, Tae Rim

AU - Yoon, Ho Il

AU - Sheen, Seung Soo

AU - Oh, Yeon Mok

AU - Park, Yong Bum

AU - Lee, Sang Do

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N2 - Background: To date, no clinical parameter has been associated with the decline in lung function other than emphysema severity in COPD. Objectives: The main purpose of this study was to explore whether the rate of lung function decline differs between COPD patients with and without exertional desaturation. Methods: A total of 224 subjects were selected from the Korean Obstructive Lung Disease cohort. Exertional desaturation was assessed using the 6-min walk test (6MWT), and defined as a post-exercise oxygen saturation (SpO2) of <90% or a ≥4% decrease. The cohort was divided into desaturator (n = 47) and non-desaturator (n = 177) groups. Results: There was a significant difference between the desaturator and non-desaturator groups in terms of the change in pre-bronchodilator forced expiratory volume in 1 s (FEV1) over a 3-year period of follow-up (p = 0.006). The mean rate of decline in FEV1 was greater in the desaturator group (33.8 ml/year) than in the non-desaturator group (11.6 ml/year). A statistically significant difference was also observed between the two groups in terms of the change in the St. George's Respiratory Questionnaire (SGRQ) total score over 3 years (p = 0.001). Conclusions: This study suggests, for the first time, that exertional desaturation may be a predictor of rapid decline in lung function in patients with COPD. The 6MWT may be a useful test to predict a rapid lung function decline in COPD.

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KW - Computed tomography

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