Exhaled nitric oxide as a better diagnostic indicator for evaluating wheeze and airway hyperresponsiveness in preschool children

Jung Won Lee, Jung Yeon Shim, Ji Won Kwon, Hyung Young Kim, Ju Hee Seo, Byoung Ju Kim, Hyo Bin Kim, So Yeon Lee, Gwang Cheon Jang, Dae-Jin Song, Woo Kyung Kim, Young Ho Jung, Soo Jong Hong

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: Fractional concentration of exhaled nitric oxide (FeNO) is a known marker of airway inflammation. The aims of this study were to evaluate FeNO, impulse oscillometry (IOS), and spirometry in preschool children and to investigate their relationship with wheeze and airway hyperresponsiveness (AHR). Methods: We performed a population-based, cross-sectional study with 561 children aged 5-6 years. A total of 544 children completed a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and eligible for the study. We measured FeNO, spirometry, methacholine bronchial provocation, and IOS. AHR was defined as the induction of a 20% decrease in FEV1(PC20) by a methacholine concentration ≤8.0 mg/dL. Results: Children who had wheeze or AHR had higher FeNO levels than children without these symptoms. However, neither IOS nor spirometry parameters showed significant differences between children with wheeze or AHR and those without. FeNO was associated with AHR, whereas IOS or spirometry parameters showed no association. Mean FeNO levels were positively correlated with a dose-response slope for methacholine, but neither IOS nor spirometry parameters showed significant correlations. Conclusions: FeNO is a more sensitive measurement of AHR and wheeze than spirometry or IOS in preschool children.

Original languageEnglish
Pages (from-to)1054-1059
Number of pages6
JournalJournal of Asthma
Volume52
Issue number10
DOIs
Publication statusPublished - 2015 Nov 26

Fingerprint

Oscillometry
Preschool Children
Spirometry
Nitric Oxide
Methacholine Chloride
Hypersensitivity
Asthma
Cross-Sectional Studies
Inflammation

Keywords

  • Airway hyperresponsiveness
  • Airway inflammation
  • Fractional exhaled nitric oxide
  • Impulse oscillometry
  • Lung function
  • Preschool children

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Exhaled nitric oxide as a better diagnostic indicator for evaluating wheeze and airway hyperresponsiveness in preschool children. / Lee, Jung Won; Shim, Jung Yeon; Kwon, Ji Won; Kim, Hyung Young; Seo, Ju Hee; Kim, Byoung Ju; Kim, Hyo Bin; Lee, So Yeon; Jang, Gwang Cheon; Song, Dae-Jin; Kim, Woo Kyung; Jung, Young Ho; Hong, Soo Jong.

In: Journal of Asthma, Vol. 52, No. 10, 26.11.2015, p. 1054-1059.

Research output: Contribution to journalArticle

Lee, JW, Shim, JY, Kwon, JW, Kim, HY, Seo, JH, Kim, BJ, Kim, HB, Lee, SY, Jang, GC, Song, D-J, Kim, WK, Jung, YH & Hong, SJ 2015, 'Exhaled nitric oxide as a better diagnostic indicator for evaluating wheeze and airway hyperresponsiveness in preschool children', Journal of Asthma, vol. 52, no. 10, pp. 1054-1059. https://doi.org/10.3109/02770903.2015.1046078
Lee, Jung Won ; Shim, Jung Yeon ; Kwon, Ji Won ; Kim, Hyung Young ; Seo, Ju Hee ; Kim, Byoung Ju ; Kim, Hyo Bin ; Lee, So Yeon ; Jang, Gwang Cheon ; Song, Dae-Jin ; Kim, Woo Kyung ; Jung, Young Ho ; Hong, Soo Jong. / Exhaled nitric oxide as a better diagnostic indicator for evaluating wheeze and airway hyperresponsiveness in preschool children. In: Journal of Asthma. 2015 ; Vol. 52, No. 10. pp. 1054-1059.
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AU - Shim, Jung Yeon

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AU - Seo, Ju Hee

AU - Kim, Byoung Ju

AU - Kim, Hyo Bin

AU - Lee, So Yeon

AU - Jang, Gwang Cheon

AU - Song, Dae-Jin

AU - Kim, Woo Kyung

AU - Jung, Young Ho

AU - Hong, Soo Jong

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N2 - Objective: Fractional concentration of exhaled nitric oxide (FeNO) is a known marker of airway inflammation. The aims of this study were to evaluate FeNO, impulse oscillometry (IOS), and spirometry in preschool children and to investigate their relationship with wheeze and airway hyperresponsiveness (AHR). Methods: We performed a population-based, cross-sectional study with 561 children aged 5-6 years. A total of 544 children completed a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and eligible for the study. We measured FeNO, spirometry, methacholine bronchial provocation, and IOS. AHR was defined as the induction of a 20% decrease in FEV1(PC20) by a methacholine concentration ≤8.0 mg/dL. Results: Children who had wheeze or AHR had higher FeNO levels than children without these symptoms. However, neither IOS nor spirometry parameters showed significant differences between children with wheeze or AHR and those without. FeNO was associated with AHR, whereas IOS or spirometry parameters showed no association. Mean FeNO levels were positively correlated with a dose-response slope for methacholine, but neither IOS nor spirometry parameters showed significant correlations. Conclusions: FeNO is a more sensitive measurement of AHR and wheeze than spirometry or IOS in preschool children.

AB - Objective: Fractional concentration of exhaled nitric oxide (FeNO) is a known marker of airway inflammation. The aims of this study were to evaluate FeNO, impulse oscillometry (IOS), and spirometry in preschool children and to investigate their relationship with wheeze and airway hyperresponsiveness (AHR). Methods: We performed a population-based, cross-sectional study with 561 children aged 5-6 years. A total of 544 children completed a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and eligible for the study. We measured FeNO, spirometry, methacholine bronchial provocation, and IOS. AHR was defined as the induction of a 20% decrease in FEV1(PC20) by a methacholine concentration ≤8.0 mg/dL. Results: Children who had wheeze or AHR had higher FeNO levels than children without these symptoms. However, neither IOS nor spirometry parameters showed significant differences between children with wheeze or AHR and those without. FeNO was associated with AHR, whereas IOS or spirometry parameters showed no association. Mean FeNO levels were positively correlated with a dose-response slope for methacholine, but neither IOS nor spirometry parameters showed significant correlations. Conclusions: FeNO is a more sensitive measurement of AHR and wheeze than spirometry or IOS in preschool children.

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