@article{8e544569248a49c985594060b0965036,
title = "Expandable and implantable bioelectronic complex for analyzing and regulating real-time activity of the urinary bladder",
abstract = "Underactive bladder or detrusor underactivity (DUA), that is, not being able to micturate, has received less attention with little research and remains unknown or limited on pathological causes and treatments as opposed to overactive bladder, although the syndrome may pose a risk of urinary infections or life-threatening kidney damage. Here, we present an integrated expandable electronic and optoelectronic complex that behaves as a single body with the elastic, time-dynamic urinary bladder with substantial volume changes up to ~300%. The system configuration of the electronics validated by the theoretical model allows conformal, seamless integration onto the urinary bladder without a glue or suture, enabling precise monitoring with various electrical components for real-time status and efficient optogenetic manipulation for urination at the desired time. In vivo experiments using diabetic DUA models demonstrate the possibility for practical uses of high-fidelity electronics in clinical trials associated with the bladder and other elastic organs.",
author = "Jang, {Tae Min} and Lee, {Joong Hoon} and Honglei Zhou and Jaesun Joo and Lim, {Bong Hee} and Huanyu Cheng and Kim, {Soo Hyun} and Kang, {Il Suk} and Lee, {Kyu Sung} and Eunkyoung Park and Hwang, {Suk Won}",
note = "Funding Information: This work was supported by the Korea University, KU-KIST Graduate School of Converging Science and Technology Program, Technology Innovation Program (20002974) funded by the Ministry of Trade, Industry and Energy (MI, Korea) and a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (grant NRF-2017R1E1A1A01075027). E.P. acknowledges the support of the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, Republic of Korea, the Ministry of Food and Drug Safety) (202012D30). Computations for this research were performed on the Pennsylvania State University's Institute for Computational and Data Sciences' Roar supercomputer. H.C. also acknowledges the support from a Doctoral New Investigator grant from the American Chemical Society Petroleum Research Fund (59021-DNI7) and NSF (ECCS-1933072). Publisher Copyright: Copyright {\textcopyright} 2020 The Authors, some rights reserved.",
year = "2020",
month = nov,
day = "11",
doi = "10.1126/sciadv.abc9675",
language = "English",
volume = "6",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "46",
}