Expansion of secretin-like G protein-coupled receptors and their peptide ligands via local duplications before and after two rounds of whole-genome duplication

Jong-Ik Hwang, Mi Jin Moon, Sumi Park, Dong Kyu Kim, Eun Bee Cho, Nui Ha, Gi Hoon Son, Kyungjin Kim, Hubert Vaudry, Jae Young Seong

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In humans, the secretin-like G protein-coupled receptor (GPCR) family comprises 15 members with 18 corresponding peptide ligand genes. Although members have been identified in a large variety of vertebrate and nonvertebrate species, the origin and relationship of these proteins remain unresolved. To address this issue, we employed large-scale genome comparisons to identify genome fragments with conserved synteny and matched these fragments to linkage groups in reconstructed early gnathostome ancestral chromosomes (GAC). This genome comparison revealed that most receptor and peptide genes were clustered in three GAC linkage groups and suggested that the ancestral forms of five peptide subfamilies (corticotropin-releasing hormone-like, calcitonin-like, parathyroid hormone-like, glucagon-like, and growth hormone-releasing hormone-like) and their cognate receptor families emerged through tandem local gene duplications before two rounds (2R) of whole-genome duplication. These subfamily genes have, then, been amplified by 2R whole-genome duplication, followed by additional local duplications and gene loss prior to the divergence of land vertebrates and teleosts. This study delineates a possible evolutionary scenario for whole secretin-like peptide and receptor family members and may shed light on evolutionary mechanisms for expansion of a gene family with a large number of paralogs.

Original languageEnglish
Pages (from-to)1119-1130
Number of pages12
JournalMolecular Biology and Evolution
Volume30
Issue number5
DOIs
Publication statusPublished - 2013 May 1

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secretin
Secretin
G-Protein-Coupled Receptors
peptide
ligand
genome
Genome
peptides
Ligands
Peptides
protein
hormone
gene
Gene Duplication
Peptide Receptors
linkage groups
genes
receptors
Genes
Vertebrates

Keywords

  • comparative genomics
  • evolution
  • G protein-coupled receptor
  • genome
  • genome duplication
  • secretin

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Expansion of secretin-like G protein-coupled receptors and their peptide ligands via local duplications before and after two rounds of whole-genome duplication. / Hwang, Jong-Ik; Moon, Mi Jin; Park, Sumi; Kim, Dong Kyu; Cho, Eun Bee; Ha, Nui; Son, Gi Hoon; Kim, Kyungjin; Vaudry, Hubert; Seong, Jae Young.

In: Molecular Biology and Evolution, Vol. 30, No. 5, 01.05.2013, p. 1119-1130.

Research output: Contribution to journalArticle

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