Experiences on conversion to once-daily advagraf and sirolimus combination in stable kidney recipients

H. Jun, C. W. Jung, M. G. Kim, K. T. Park

Research output: Contribution to journalArticle

1 Citation (Scopus)


In transplant recipients, nephrotoxicity due to long-term use of calcineurin inhibitor (CNI) is a serious problem that cannot be overlooked. Medication compliance can cause graft failure in transplant recipients who are bound to long-term medication. In this study, 36 patients who underwent conversion to once-daily Advagraft and sirolimus combination at Korea University Anam Hospital from September 2011 to March 2013 were retrospectively reviewed at 3 and 6 months for laboratory findings, mean arterial pressure (MAP), and so on. After conversion, serum creatinine level and glomerular filtration rate (GFR) decreased significantly at 3 months (P =.024 and P <.001, respectively). Fasting serum glucose level and proteinuria increased significantly at 6 months (P =.016 and P =.030, respectively). The impact of time after conversion at 3 months was significantly related to the increase in postoperative estimated glomerular filtration rate (eGFR). Graft rejection, morbidity, and mortality did not occur within the study period. A once-daily Advagraf and sirolimus regimen can be a novel standard regimen in stable kidney recipients due to its effects in improving renal function and convenience for patients.

Original languageEnglish
Pages (from-to)400-402
Number of pages3
JournalTransplantation Proceedings
Issue number2
Publication statusPublished - 2014 Mar

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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