Experimental Analysis on the Properties of Polypyrrole as Drug Delivery System Materials

Seung Ki Lee, Sang Jo Lee, Sung Hwan Cho, James Jungho Pak, Byungkyu Kim

Research output: Contribution to journalConference article

Abstract

A quantitative analysis of drug release characteristics of polypyrrole (PPy) was performed for its application to a drug delivery system (DDS). The incorporation of various chemical substances into the PPy and controlling its release with the externally applied voltage to the PPy are possible. A qualitative drug release characteristics of the PPy was first examined using an indicator, phenolred and then the quantitative analysis was performed using salicylate as a dopant. A drug release characteristics with time was thoroughly investigated while varying the electrode area, polymerization time, the applied voltage for drug release. Based on these quantitative results, a preliminary experiment was carried out to check the feasibility of the PPy applicable to the neuronal system. Experimental results show that a neurotransmitter was released from the PPy with the externally applied voltage and hence the PPy can be applicable in a neuronal system.

Original languageEnglish
Pages (from-to)338-348
Number of pages11
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5051
DOIs
Publication statusPublished - 2003 Nov 27
EventPROCEEDINGS OF SPIE SPIE - The International Society for Optical Engineering: Smart Structures and Materials 2003 Electroactive Polymer Actuators and Devices (EAPAD) - San Diego, CA, United States
Duration: 2003 Mar 32003 Mar 6

Keywords

  • Drug delivery system
  • Neurotransmitter
  • Polypyrrole

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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