Abstract
A quantitative analysis of drug release characteristics of polypyrrole (PPy) was performed for its application to a drug delivery system (DDS). The incorporation of various chemical substances into the PPy and controlling its release with the externally applied voltage to the PPy are possible. A qualitative drug release characteristics of the PPy was first examined using an indicator, phenolred and then the quantitative analysis was performed using salicylate as a dopant. A drug release characteristics with time was thoroughly investigated while varying the electrode area, polymerization time, the applied voltage for drug release. Based on these quantitative results, a preliminary experiment was carried out to check the feasibility of the PPy applicable to the neuronal system. Experimental results show that a neurotransmitter was released from the PPy with the externally applied voltage and hence the PPy can be applicable in a neuronal system.
| Original language | English |
|---|---|
| Pages (from-to) | 338-348 |
| Number of pages | 11 |
| Journal | Proceedings of SPIE - The International Society for Optical Engineering |
| Volume | 5051 |
| DOIs | |
| Publication status | Published - 2003 |
| Event | PROCEEDINGS OF SPIE SPIE - The International Society for Optical Engineering: Smart Structures and Materials 2003 Electroactive Polymer Actuators and Devices (EAPAD) - San Diego, CA, United States Duration: 2003 Mar 3 → 2003 Mar 6 |
Keywords
- Drug delivery system
- Neurotransmitter
- Polypyrrole
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering