Experimental investigation of pulsatility effect on the deformability and hemolysis of blood cells

Yang Jun Kang, Myoung Gon Kim, Kuk Hui Son, Choon Hak Lim, Ho Sung Son, Sang Youl Yoon, Hyuk Sang Kwon, Sung Yang

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

In this study, we investigated the differences between pulsatile cardiopulmonary bypass (CPB) procedure and nonpulsatile CPB procedure in terms of their effects on hemolysis and deformability of red blood cells (RBCs) under various shear stress conditions. In order to research the effects on hemolysis and deformability, four parameters - free hemoglobin (fHb) concentration, normalized index of hemolysis (NIH), deformability index (DI) of RBCs, and elongation index of RBCs - have been deeply investigated. For these investigations, two randomly assigned adult mongrel dog groups - nonpulsatile group (NP, n = 6) and pulsatile group (P, n = 6) - were examined. According to our results, both types of perfusion did not show any statistical differences in terms of the concentrations of fHb as well as NIH. In addition, there were no significant differences in RBC deformability between perfusion types within an operation time of 3 h. Therefore, our studies suggest that pulsatile perfusion has no significant difference from nonpulsatile perfusion in terms of hemolysis and deformability of RBCs.

Original languageEnglish
Pages (from-to)E103-E109
JournalArtificial Organs
Volume34
Issue number4
DOIs
Publication statusPublished - 2010 Apr

Keywords

  • Deformability index
  • Elongation index
  • Hemolysis
  • Normalized index of hemolysis
  • Plasma free hemoglobin
  • Pulsatility

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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