Exploring the human diseasome

The human disease network

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Advances in genome-scale molecular biology and molecular genetics have greatly elevated our knowledge on the basic components of human biology and diseases. At the same time, the importance of cellular networks between those biological components is increasingly appreciated. Built upon these recent technological and conceptual advances, a new discipline called the network medicine, an approach to understand human diseases from a network point-of-view, is about to emerge. In this review article, we will survey some recent endeavours along this direction, centred on the concept and applications of the human diseasome and the human disease network. Questions, and partial answers thereof, such as how the connectivity between molecular parts translates into the relationships between the related disorders on a global scale and how central the disease-causing genetic components are in the cellular network, will be discussed. The use of the diseasome in combination with various interactome networks and other disease-related factors is also reviewed.

Original languageEnglish
Article numberels032
Pages (from-to)533-542
Number of pages10
JournalBriefings in Functional Genomics
Volume11
Issue number6
DOIs
Publication statusPublished - 2012 Nov 1

Fingerprint

Molecular Biology
Inborn Genetic Diseases
Molecular biology
Medicine
Genome
Genes
Surveys and Questionnaires
Direction compound
Genetics

Keywords

  • Cellular network
  • Diseasome
  • Human disease network
  • Interactome
  • Network medicine

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Molecular Biology

Cite this

Exploring the human diseasome : The human disease network. / Goh, Kwang-Il; Choi, In-Geol.

In: Briefings in Functional Genomics, Vol. 11, No. 6, els032, 01.11.2012, p. 533-542.

Research output: Contribution to journalArticle

@article{cee5b2aadcfc4107902088db24b2b41d,
title = "Exploring the human diseasome: The human disease network",
abstract = "Advances in genome-scale molecular biology and molecular genetics have greatly elevated our knowledge on the basic components of human biology and diseases. At the same time, the importance of cellular networks between those biological components is increasingly appreciated. Built upon these recent technological and conceptual advances, a new discipline called the network medicine, an approach to understand human diseases from a network point-of-view, is about to emerge. In this review article, we will survey some recent endeavours along this direction, centred on the concept and applications of the human diseasome and the human disease network. Questions, and partial answers thereof, such as how the connectivity between molecular parts translates into the relationships between the related disorders on a global scale and how central the disease-causing genetic components are in the cellular network, will be discussed. The use of the diseasome in combination with various interactome networks and other disease-related factors is also reviewed.",
keywords = "Cellular network, Diseasome, Human disease network, Interactome, Network medicine",
author = "Kwang-Il Goh and In-Geol Choi",
year = "2012",
month = "11",
day = "1",
doi = "10.1093/bfgp/els032",
language = "English",
volume = "11",
pages = "533--542",
journal = "Briefings in Functional Genomics",
issn = "2041-2649",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Exploring the human diseasome

T2 - The human disease network

AU - Goh, Kwang-Il

AU - Choi, In-Geol

PY - 2012/11/1

Y1 - 2012/11/1

N2 - Advances in genome-scale molecular biology and molecular genetics have greatly elevated our knowledge on the basic components of human biology and diseases. At the same time, the importance of cellular networks between those biological components is increasingly appreciated. Built upon these recent technological and conceptual advances, a new discipline called the network medicine, an approach to understand human diseases from a network point-of-view, is about to emerge. In this review article, we will survey some recent endeavours along this direction, centred on the concept and applications of the human diseasome and the human disease network. Questions, and partial answers thereof, such as how the connectivity between molecular parts translates into the relationships between the related disorders on a global scale and how central the disease-causing genetic components are in the cellular network, will be discussed. The use of the diseasome in combination with various interactome networks and other disease-related factors is also reviewed.

AB - Advances in genome-scale molecular biology and molecular genetics have greatly elevated our knowledge on the basic components of human biology and diseases. At the same time, the importance of cellular networks between those biological components is increasingly appreciated. Built upon these recent technological and conceptual advances, a new discipline called the network medicine, an approach to understand human diseases from a network point-of-view, is about to emerge. In this review article, we will survey some recent endeavours along this direction, centred on the concept and applications of the human diseasome and the human disease network. Questions, and partial answers thereof, such as how the connectivity between molecular parts translates into the relationships between the related disorders on a global scale and how central the disease-causing genetic components are in the cellular network, will be discussed. The use of the diseasome in combination with various interactome networks and other disease-related factors is also reviewed.

KW - Cellular network

KW - Diseasome

KW - Human disease network

KW - Interactome

KW - Network medicine

UR - http://www.scopus.com/inward/record.url?scp=84870381724&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870381724&partnerID=8YFLogxK

U2 - 10.1093/bfgp/els032

DO - 10.1093/bfgp/els032

M3 - Article

VL - 11

SP - 533

EP - 542

JO - Briefings in Functional Genomics

JF - Briefings in Functional Genomics

SN - 2041-2649

IS - 6

M1 - els032

ER -