Exposure to dichlorodiphenyltrichloroethane and the risk of breast cancer: A systematic review and meta-analysis

Jae Hong Park, Eun Shil Cha, Yousun Ko, Myung Sil Hwang, Jin Hwan Hong, Won Jin Lee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives: This study extended and updated a meta-analysis of the association between exposure to dichlorodiphenyltrichloroethane (DDT) and the risk of breast cancer. Methods: We reviewed the published literature on exposure to DDE and breast cancer risk to update a meta-analysis from 2004. The total of 35 studies included 16 hospital-based case-control studies, 11 population-based case-control studies, and 10 nested case-control studies identified through keyword searches in the PubMed and EMBASE databases. Results: The summary odds ratio (OR) for the identified studies was 1.03 (95% confidence interval 0.95-1.12) and the overall heterogeneity in the OR was observed (I2 = 40.9; p = 0.006). Subgroup meta-analyses indicated no significant association between exposure to DDE and breast cancer risk by the type of design, study years, biological specimen, and geographical region of the study, except from population-based case-control studies with estimated DDE levels in serum published in 1990s. Conclusion: Existing studies do not support the view that DDE increases the risk of breast cancer in humans. However, further studies incorporating more detailed information on DDT exposure and other potential risk factors for breast cancer are needed.

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalOsong Public Health and Research Perspectives
Volume5
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Dichlorodiphenyl Dichloroethylene
Meta-Analysis
Case-Control Studies
Breast Neoplasms
Odds Ratio
PubMed
Population
Databases
Confidence Intervals
Serum

Keywords

  • Breast cancer
  • Dichlorodiphenyldichloroethylene
  • Meta-analysis
  • Pesticide exposure
  • Systematic review

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Exposure to dichlorodiphenyltrichloroethane and the risk of breast cancer : A systematic review and meta-analysis. / Park, Jae Hong; Cha, Eun Shil; Ko, Yousun; Hwang, Myung Sil; Hong, Jin Hwan; Lee, Won Jin.

In: Osong Public Health and Research Perspectives, Vol. 5, No. 2, 01.01.2014, p. 77-84.

Research output: Contribution to journalArticle

Park, Jae Hong ; Cha, Eun Shil ; Ko, Yousun ; Hwang, Myung Sil ; Hong, Jin Hwan ; Lee, Won Jin. / Exposure to dichlorodiphenyltrichloroethane and the risk of breast cancer : A systematic review and meta-analysis. In: Osong Public Health and Research Perspectives. 2014 ; Vol. 5, No. 2. pp. 77-84.
@article{3589ed1833464589850ae61b9820ef3b,
title = "Exposure to dichlorodiphenyltrichloroethane and the risk of breast cancer: A systematic review and meta-analysis",
abstract = "Objectives: This study extended and updated a meta-analysis of the association between exposure to dichlorodiphenyltrichloroethane (DDT) and the risk of breast cancer. Methods: We reviewed the published literature on exposure to DDE and breast cancer risk to update a meta-analysis from 2004. The total of 35 studies included 16 hospital-based case-control studies, 11 population-based case-control studies, and 10 nested case-control studies identified through keyword searches in the PubMed and EMBASE databases. Results: The summary odds ratio (OR) for the identified studies was 1.03 (95{\%} confidence interval 0.95-1.12) and the overall heterogeneity in the OR was observed (I2 = 40.9; p = 0.006). Subgroup meta-analyses indicated no significant association between exposure to DDE and breast cancer risk by the type of design, study years, biological specimen, and geographical region of the study, except from population-based case-control studies with estimated DDE levels in serum published in 1990s. Conclusion: Existing studies do not support the view that DDE increases the risk of breast cancer in humans. However, further studies incorporating more detailed information on DDT exposure and other potential risk factors for breast cancer are needed.",
keywords = "Breast cancer, Dichlorodiphenyldichloroethylene, Meta-analysis, Pesticide exposure, Systematic review",
author = "Park, {Jae Hong} and Cha, {Eun Shil} and Yousun Ko and Hwang, {Myung Sil} and Hong, {Jin Hwan} and Lee, {Won Jin}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.phrp.2014.02.001",
language = "English",
volume = "5",
pages = "77--84",
journal = "Osong Public Health and Research Perspectives",
issn = "2210-9099",
publisher = "Elsevier Korea",
number = "2",

}

TY - JOUR

T1 - Exposure to dichlorodiphenyltrichloroethane and the risk of breast cancer

T2 - A systematic review and meta-analysis

AU - Park, Jae Hong

AU - Cha, Eun Shil

AU - Ko, Yousun

AU - Hwang, Myung Sil

AU - Hong, Jin Hwan

AU - Lee, Won Jin

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objectives: This study extended and updated a meta-analysis of the association between exposure to dichlorodiphenyltrichloroethane (DDT) and the risk of breast cancer. Methods: We reviewed the published literature on exposure to DDE and breast cancer risk to update a meta-analysis from 2004. The total of 35 studies included 16 hospital-based case-control studies, 11 population-based case-control studies, and 10 nested case-control studies identified through keyword searches in the PubMed and EMBASE databases. Results: The summary odds ratio (OR) for the identified studies was 1.03 (95% confidence interval 0.95-1.12) and the overall heterogeneity in the OR was observed (I2 = 40.9; p = 0.006). Subgroup meta-analyses indicated no significant association between exposure to DDE and breast cancer risk by the type of design, study years, biological specimen, and geographical region of the study, except from population-based case-control studies with estimated DDE levels in serum published in 1990s. Conclusion: Existing studies do not support the view that DDE increases the risk of breast cancer in humans. However, further studies incorporating more detailed information on DDT exposure and other potential risk factors for breast cancer are needed.

AB - Objectives: This study extended and updated a meta-analysis of the association between exposure to dichlorodiphenyltrichloroethane (DDT) and the risk of breast cancer. Methods: We reviewed the published literature on exposure to DDE and breast cancer risk to update a meta-analysis from 2004. The total of 35 studies included 16 hospital-based case-control studies, 11 population-based case-control studies, and 10 nested case-control studies identified through keyword searches in the PubMed and EMBASE databases. Results: The summary odds ratio (OR) for the identified studies was 1.03 (95% confidence interval 0.95-1.12) and the overall heterogeneity in the OR was observed (I2 = 40.9; p = 0.006). Subgroup meta-analyses indicated no significant association between exposure to DDE and breast cancer risk by the type of design, study years, biological specimen, and geographical region of the study, except from population-based case-control studies with estimated DDE levels in serum published in 1990s. Conclusion: Existing studies do not support the view that DDE increases the risk of breast cancer in humans. However, further studies incorporating more detailed information on DDT exposure and other potential risk factors for breast cancer are needed.

KW - Breast cancer

KW - Dichlorodiphenyldichloroethylene

KW - Meta-analysis

KW - Pesticide exposure

KW - Systematic review

UR - http://www.scopus.com/inward/record.url?scp=84899951987&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899951987&partnerID=8YFLogxK

U2 - 10.1016/j.phrp.2014.02.001

DO - 10.1016/j.phrp.2014.02.001

M3 - Article

AN - SCOPUS:84899951987

VL - 5

SP - 77

EP - 84

JO - Osong Public Health and Research Perspectives

JF - Osong Public Health and Research Perspectives

SN - 2210-9099

IS - 2

ER -