Exposure to lead and mercury through breastfeeding during the first month of life: A CHECK cohort study

Yelim Park, Aram Lee, Kyungho Choi, Hai Joong Kim, Jeong Jae Lee, Gyuyeon Choi, Sungjoo Kim, Su Young Kim, Geum-Joon Cho, Eunsook Suh, Sung Koo Kim, So-Hee Eun, Soyong Eom, Seunghyo Kim, Gun Ha Kim, Hyo Bang Moon, Sungkyoon Kim, Sooran Choi, Young Don Kim, Jinho KimJeongim Park

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Mercury and lead are naturally occurring toxicants and are responsible for various health issues including neurobehavioral and developmental disorders. Because of crucial synchronized developmental processes occurring at the early stage of life, infancy and childhood are considered as among the most susceptible windows to the exposure to these metals. Breastmilk is often the only source of nutrition during the first months of life. As breastmilk can be contaminated with these metals, breastfeeding may serve as a significant route of heavy metal exposure among infants. In order to understand current levels of exposure to mercury and lead through breastfeeding, and their associated risks, a total of 157 lactating mothers were recruited from Children's Health and Environmental Chemicals of Korea (CHECK) cohort, and breastmilk samples were collected at 15 and 30 days after delivery (n = 207). Mercury was detected from 100% of breastmilk with a median concentration of 0.59 μg/L, and lead was detected in 77% of the samples with a median at 4.71 μg/L. Higher concentrations of lead were found in the 30- day breastmilk than in the 15-day. Up to 45% of the breastmilk samples exceeded the normal range of the breastmilk lead suggested by WHO. Based on Monte Carlo simulation, about 71% of 15 days old infants and 56% of 30 days old infants were estimated at risk due to lead exposure through breastfeeding. Considering vulnerability of infants and well-known neurological toxicity of these metals, further studies to identify major exposure sources that contribute the lead concentration in breastmilk and health implication of early life stage exposure to lead among the breastfed infants are warranted.

Original languageEnglish
Pages (from-to)876-883
Number of pages8
JournalScience of the Total Environment
Volume612
DOIs
Publication statusPublished - 2018 Jan 15

Fingerprint

breastfeeding
child health
Mercury
Lead
Health
Metals
metal
Nutrition
Heavy Metals
Heavy metals
Toxicity
chemical
mercury
exposure
nutrition
vulnerability
infant
heavy metal
toxicity
simulation

Keywords

  • Breastmilk
  • CHECK
  • Daily intake
  • Lead
  • Mercury
  • Probabilistic risk estimation

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution

Cite this

Exposure to lead and mercury through breastfeeding during the first month of life : A CHECK cohort study. / Park, Yelim; Lee, Aram; Choi, Kyungho; Kim, Hai Joong; Lee, Jeong Jae; Choi, Gyuyeon; Kim, Sungjoo; Kim, Su Young; Cho, Geum-Joon; Suh, Eunsook; Kim, Sung Koo; Eun, So-Hee; Eom, Soyong; Kim, Seunghyo; Kim, Gun Ha; Moon, Hyo Bang; Kim, Sungkyoon; Choi, Sooran; Kim, Young Don; Kim, Jinho; Park, Jeongim.

In: Science of the Total Environment, Vol. 612, 15.01.2018, p. 876-883.

Research output: Contribution to journalArticle

Park, Y, Lee, A, Choi, K, Kim, HJ, Lee, JJ, Choi, G, Kim, S, Kim, SY, Cho, G-J, Suh, E, Kim, SK, Eun, S-H, Eom, S, Kim, S, Kim, GH, Moon, HB, Kim, S, Choi, S, Kim, YD, Kim, J & Park, J 2018, 'Exposure to lead and mercury through breastfeeding during the first month of life: A CHECK cohort study', Science of the Total Environment, vol. 612, pp. 876-883. https://doi.org/10.1016/j.scitotenv.2017.08.079
Park, Yelim ; Lee, Aram ; Choi, Kyungho ; Kim, Hai Joong ; Lee, Jeong Jae ; Choi, Gyuyeon ; Kim, Sungjoo ; Kim, Su Young ; Cho, Geum-Joon ; Suh, Eunsook ; Kim, Sung Koo ; Eun, So-Hee ; Eom, Soyong ; Kim, Seunghyo ; Kim, Gun Ha ; Moon, Hyo Bang ; Kim, Sungkyoon ; Choi, Sooran ; Kim, Young Don ; Kim, Jinho ; Park, Jeongim. / Exposure to lead and mercury through breastfeeding during the first month of life : A CHECK cohort study. In: Science of the Total Environment. 2018 ; Vol. 612. pp. 876-883.
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abstract = "Mercury and lead are naturally occurring toxicants and are responsible for various health issues including neurobehavioral and developmental disorders. Because of crucial synchronized developmental processes occurring at the early stage of life, infancy and childhood are considered as among the most susceptible windows to the exposure to these metals. Breastmilk is often the only source of nutrition during the first months of life. As breastmilk can be contaminated with these metals, breastfeeding may serve as a significant route of heavy metal exposure among infants. In order to understand current levels of exposure to mercury and lead through breastfeeding, and their associated risks, a total of 157 lactating mothers were recruited from Children's Health and Environmental Chemicals of Korea (CHECK) cohort, and breastmilk samples were collected at 15 and 30 days after delivery (n = 207). Mercury was detected from 100{\%} of breastmilk with a median concentration of 0.59 μg/L, and lead was detected in 77{\%} of the samples with a median at 4.71 μg/L. Higher concentrations of lead were found in the 30- day breastmilk than in the 15-day. Up to 45{\%} of the breastmilk samples exceeded the normal range of the breastmilk lead suggested by WHO. Based on Monte Carlo simulation, about 71{\%} of 15 days old infants and 56{\%} of 30 days old infants were estimated at risk due to lead exposure through breastfeeding. Considering vulnerability of infants and well-known neurological toxicity of these metals, further studies to identify major exposure sources that contribute the lead concentration in breastmilk and health implication of early life stage exposure to lead among the breastfed infants are warranted.",
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AU - Park, Jeongim

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