Expression of β-tubulin isotypes in classical Hodgkin's lymphoma

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Microtubules consist of heterodimers of α- and β-tubulin. Aberrant expression of specific β-tubulin isotype is associated with resistance to chemotherapy in malignant tumors. In this study, we examined the expressions of β-tubulin isotypes in classical Hodgkin's lymphoma (cHL) by immunohistochemistry. Among the β-tubulin isotypes, class II β-tubulin (31/34, 91%) was most frequently overexpressed in the cytoplasm of almost all Hodgkin's and Reed-Sternberg (HRS) cells, followed by class I β-tubulin (18/34, 53%) and class III β-tubulin (12/34, 35%). Class IV β-tubulin was not expressed in any cHL case. Class I β-tubulin was expressed in the background lymphoid cells as well as the HRS cells. Thus, our results indicate that class II β-tubulin may be very useful for immunohistochemical diagnosis of cHL, and provide valuable information for the potential application of β-tubulin isotype-specific targeting.

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalPathology International
Volume62
Issue number4
DOIs
Publication statusPublished - 2012 Apr 1

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Tubulin
Hodgkin Disease
Reed-Sternberg Cells
Microtubules
Cytoplasm
Immunohistochemistry
Lymphocytes
Drug Therapy

Keywords

  • Hodgkin's lymphoma
  • Microtubule
  • Tubulin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Expression of β-tubulin isotypes in classical Hodgkin's lymphoma. / Choi, Jung-Woo; Lee, Ju-Han; Kim, Young Sik.

In: Pathology International, Vol. 62, No. 4, 01.04.2012, p. 287-290.

Research output: Contribution to journalArticle

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