Expression of androgen receptors in astrocytoma

Yong Gu Chung, Han Kyeom Kim, Hoon Kap Lee, Ki Chan Lee

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    Thirty-two cases of surgically removed astrocytoma were evaluated for the expression of androgen receptors(ARs) immunohistochemically and the relationships between androgen receptors, DNA ploidy pattern, and survival of patients were studied. The cases included 18 grade I/II astrocytomas, 4 anaplastic astrocytomas, and 10 glioblastoma multiforme(GBM). Positive AR was present in 12 out of 32 cases(38%), which consisted of 5 cases in grade I/II(28%), 3 cases in anaplastic astrocytoma(75%), and 4 cases in GBM(40%). For both low and high grade astrocytomas, sex and ploidy pattern were not correlated with expression of the androgen receptors. Androgen receptor expression did not significantly affect the survival time. This study confirms previous reports of a low incidence of androgen receptors in astrocytomas. In addition, it shows that expression of androgen receptors is not correlated with DNA ploidy pattern and survival of patients in astrocytoma.

    Original languageEnglish
    Pages (from-to)517-521
    Number of pages5
    JournalJournal of Korean medical science
    Volume11
    Issue number6
    DOIs
    Publication statusPublished - 1996 Dec

    Keywords

    • Androgen receptors
    • Astrocytoma
    • Ploidy
    • Survival

    ASJC Scopus subject areas

    • Medicine(all)

    Fingerprint

    Dive into the research topics of 'Expression of androgen receptors in astrocytoma'. Together they form a unique fingerprint.

    Cite this