Expression of connexin29 and 32 in the penumbra region after traumatic brain injury of mice

Younghye Moon, So Yoen Choi, Kyungjin Kim, Hyun Kim, Woong Sun

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Connexins (Cx) are transmembrane proteins forming vertebrate gap junction channels for direct cell-cell communication. We found that the expressions of two Cx family members, Cx29 and Cx32, were progressively increased in the sharp border of injury penumbra regions after cryotraumatic brain injury. Although these two Cxs are expressed exclusively in the oligodendrocytes in the normal cerebral cortex, their expressions were increased in the astrocytes and microglia localized in the injury border. Highly selective induction of Cxs in the injury border suggests that altered Cxs may contribute to the propagations of injury-related and/or regeneration signals after acute brain injury.

Original languageEnglish
Pages (from-to)1135-1139
Number of pages5
JournalNeuroreport
Volume21
Issue number18
DOIs
Publication statusPublished - 2010 Dec 29

Keywords

  • Connexin
  • Gap junction
  • Hemichannel
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)

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