Expression of epidermal growth factor receptor and its ligands in chronic sinusitis

Heung Man Lee, Jin Ho Choi, Soon Jae Hwang, Sungwon Chae, Sang Hag Lee

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The epidermal growth factor receptor (EGF-R) system plays a crucial role in mucus production in vitro and in rats. However, the role of the EGF-R system in humans is not known. We compared the localization of EGF-R and its ligands (epidermal growth factor and transforming growth factor ct) in the epithelia of sinuses with chronic sinusitis and in those of healthy controls. Immunohistochemical techniques were employed to identify the presence of EGF-R and its ligands in the sinus mucosa. We found EGF-R in goblet cells, basal cells, and submucosal gland cells, but not in ciliated cells. Immunoreactivity for both epidermal growth factor and transforming growth factor ct was found in the epithelial cells and inflammatory cells and in some submucosal gland cells. There was stronger staining of EGF-R and its ligand proteins in chronic sinusitis specimens than in controls. The interrelated localization of EGF-R and its ligands suggests a role in mucus production in the epithelium of the sinus mucosa.

Original languageEnglish
Pages (from-to)132-138
Number of pages7
JournalAnnals of Otology, Rhinology and Laryngology
Volume112
Issue number2
Publication statusPublished - 2003 Feb 1

Fingerprint

Sinusitis
Epidermal Growth Factor Receptor
Ligands
Transforming Growth Factors
Mucus
Epidermal Growth Factor
Mucous Membrane
Epithelium
Goblet Cells
Epithelial Cells
Staining and Labeling
Proteins

Keywords

  • Chronic sinusitis
  • Epidermal growth factor
  • Epidermal growth factor receptor
  • Transforming growth factor α

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Expression of epidermal growth factor receptor and its ligands in chronic sinusitis. / Lee, Heung Man; Choi, Jin Ho; Hwang, Soon Jae; Chae, Sungwon; Lee, Sang Hag.

In: Annals of Otology, Rhinology and Laryngology, Vol. 112, No. 2, 01.02.2003, p. 132-138.

Research output: Contribution to journalArticle

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