TY - JOUR
T1 - Expression of estrogen receptor, progesterone receptor, and Ki67 in normal breast tissue in relation to subsequent risk of breast cancer
AU - Oh, Hannah
AU - Eliassen, A. Heather
AU - Wang, Molin
AU - Smith-Warner, Stephanie A.
AU - Beck, Andrew H.
AU - Schnitt, Stuart J.
AU - Collins, Laura C.
AU - Connolly, James L.
AU - Montaser-Kouhsari, Laleh
AU - Polyak, Kornelia
AU - Tamimi, Rulla M.
N1 - Funding Information:
We thank the participants and staff of the Nurses’ Health Study and Nurses’ Health Study II for their valuable contributions as well as the following state cancer registries for their help: A.L., A.Z., A.R., C.A., C.O., C.T., D.E., F.L., G.A., I.D., I.L., I.N., I.A., K.Y., L.A., M. E., M.D., M.A., M.I., N.E., N.H., N.J., N.Y., N.C., N.D., O.H., O.K., O.R., P.A., R.I., S.C., T.N., T.X., V.A., W.A., and W.Y. The authors assume full responsibility for analyses and interpretation of these data. This work was supported by the National Cancer Institute UM1 CA186107, UM1 CA176726, P01 CA87969, T32 CA09001 (HO), R01 CA046575 (RMT), CA050385, Avon Foundation (RMT), and the Susan G. Komen Foundation (RMT).
Publisher Copyright:
© The Author(s) 2016.
PY - 2016/12/14
Y1 - 2016/12/14
N2 - Although expression of estrogen receptor (ER), progesterone receptor (PR), and cell proliferation marker Ki67 serve as predictive and prognostic factors in breast cancers, little is known about their roles in normal breast tissue. Here in a nested case–control study within the Nurses’ Health Studies (90 cases, 297 controls), we evaluated their expression levels in normal breast epithelium in relation to subsequent breast cancer risk among women with benign breast disease. Tissue microarrays were constructed using cores obtained from benign biopsies containing normal terminal duct lobular units and immunohistochemical stained for these markers. We found PR and Ki67 expression was non-significantly but positively associated with subsequent breast cancer risk, whereas ER expression was non-significantly inversely associated. After stratifying by lesion subtype, Ki67 was significantly associated with higher risk among women with proliferative lesions with atypical hyperplasia. However, given the small sample size, further studies are required to confirm these results.
AB - Although expression of estrogen receptor (ER), progesterone receptor (PR), and cell proliferation marker Ki67 serve as predictive and prognostic factors in breast cancers, little is known about their roles in normal breast tissue. Here in a nested case–control study within the Nurses’ Health Studies (90 cases, 297 controls), we evaluated their expression levels in normal breast epithelium in relation to subsequent breast cancer risk among women with benign breast disease. Tissue microarrays were constructed using cores obtained from benign biopsies containing normal terminal duct lobular units and immunohistochemical stained for these markers. We found PR and Ki67 expression was non-significantly but positively associated with subsequent breast cancer risk, whereas ER expression was non-significantly inversely associated. After stratifying by lesion subtype, Ki67 was significantly associated with higher risk among women with proliferative lesions with atypical hyperplasia. However, given the small sample size, further studies are required to confirm these results.
UR - http://www.scopus.com/inward/record.url?scp=85014378611&partnerID=8YFLogxK
U2 - 10.1038/npjbcancer.2016.32
DO - 10.1038/npjbcancer.2016.32
M3 - Article
AN - SCOPUS:85014378611
SN - 2374-4677
VL - 2
JO - npj Breast Cancer
JF - npj Breast Cancer
IS - 1
M1 - 16032
ER -
