Expression of ezrin in subventricular zone neural stem cells and their progeny in adult and developing mice

Younghye Moon, Joo Yeon Kim, So Yoen Choi, Hyo Min Cho, Hyun Kim, Woong Sun

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Ezrin is a member of the ezrin-radixin-moesin (ERM) family of proteins, which link the cytoskeleton and cell membrane. ERM proteins are involved in pivotal cellular functions including cell-matrix recognition, cell-cell communication, and cell motility. Several recent studies have shown that ERM proteins are expressed in specific cell types of the adult rostral migratory stream (RMS). In this study, we found that ERM proteins are expressed highly in the early postnatal RMS and the ventricular zone of embryonic cerebral cortex, suggesting that these proteins may be expressed by neural progenitors. Furthermore, whereas ezrin previously was found to be expressed exclusively by astrocytes of the adult RMS, we found that ezrin-expressing cells also expressed the markers for indicating neuroblasts in vivo and in vitro, and that ezrin expression by neuroblasts decreases progressively as neuroblasts migrate. Using in vitro differentiation of adult neural stem cells, we found that ezrin is expressed by neural stem cells and their progeny (neuroblasts and astrocytes), but not by oligodendrocytic progeny. Collectively our findings demonstrate that adult neural stem cells and neuroblasts express ezrin and that ezrin may be involved in intracellular actin remodeling.

Original languageEnglish
Pages (from-to)403-413
Number of pages11
JournalHistochemistry and Cell Biology
Volume139
Issue number3
DOIs
Publication statusPublished - 2013 Mar 1

Fingerprint

Neural Stem Cells
Lateral Ventricles
Adult Stem Cells
Astrocytes
Proteins
ezrin
Cytoskeleton
Cell Communication
Cerebral Cortex
Cell Movement
Actins
Cell Membrane

Keywords

  • ERM protein
  • Ezrin
  • Neural stem cell
  • Neuroblast
  • Rostral migratory stream

ASJC Scopus subject areas

  • Cell Biology
  • Histology
  • Medical Laboratory Technology
  • Molecular Biology

Cite this

Expression of ezrin in subventricular zone neural stem cells and their progeny in adult and developing mice. / Moon, Younghye; Kim, Joo Yeon; Choi, So Yoen; Cho, Hyo Min; Kim, Hyun; Sun, Woong.

In: Histochemistry and Cell Biology, Vol. 139, No. 3, 01.03.2013, p. 403-413.

Research output: Contribution to journalArticle

Moon, Younghye ; Kim, Joo Yeon ; Choi, So Yoen ; Cho, Hyo Min ; Kim, Hyun ; Sun, Woong. / Expression of ezrin in subventricular zone neural stem cells and their progeny in adult and developing mice. In: Histochemistry and Cell Biology. 2013 ; Vol. 139, No. 3. pp. 403-413.
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