Expression of GLI1 correlates with expression of lymphangiogenesis proteins, vascular endothelial growth factor c and vascular endothelial growth factor receptor 3, in colorectal cancer

Kwang Dae Hong, Youngseok Lee, Baek-Hui Kim, Sun Il Lee, Hong Young Moon

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9 Citations (Scopus)

Abstract

Aberrant activation of the hedgehog (Hh) signaling pathway is associated with tumorigenesis in various tissues. In colorectal cancer (CRC), evidence for Hh activation is inconsistent, and the relationship between the Hh signaling pathway and lymphangiogenesis has not been studied. The aim of this study was to determine the relationship between Hh signaling and lymphangiogenesis and the association of this relationship with lymph node metastasis in CRC. We investigated 189 patients who underwent curative surgical resection for CRC between 2002 and 2004 at Korea University Guro Hospital. Paraffin-embedded specimens of colorectal adenocarcinoma and adjacent normal mucosa were evaluated. Immunohistochemical staining for Sonic hedgehog (Shh), Gli1, vascular endothelial growth factor C (VEGFC), and VEGF receptor 3 (VEGFR3) was performed for each specimen. Tumor specimen showed significantly strong staining of Shh, Gli1, VEGFC, and VEGFR3 compared with a normal specimen. Shh expression was not associated with Gli1 expression. Gli1 expression correlated positively with VEGFC and VEGFR3 expression (P\0.05 in both) but not with lymph node metastasis. Activation of the Hh signaling pathway associated with Gli1 promotes expression of lymphangiogenesis proteins, VEGFC and VEGFR3, in CRC. Further studies are necessary to determine the association of this relationship with lymph node metastasis in CRC. Copyright Southeastern Surgical Congress. All rights reserved.

Original languageEnglish
Pages (from-to)198-204
Number of pages7
JournalAmerican Surgeon
Volume79
Issue number2
Publication statusPublished - 2013 Feb 1

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Vascular Endothelial Growth Factor Receptor-3
Lymphangiogenesis
Vascular Endothelial Growth Factor C
Vascular Endothelial Growth Factor A
Colorectal Neoplasms
Lymph Nodes
Neoplasm Metastasis
Proteins
Staining and Labeling
Korea
Paraffin
Carcinogenesis
Mucous Membrane
Adenocarcinoma
human FLT4 protein
Neoplasms

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

Cite this

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title = "Expression of GLI1 correlates with expression of lymphangiogenesis proteins, vascular endothelial growth factor c and vascular endothelial growth factor receptor 3, in colorectal cancer",
abstract = "Aberrant activation of the hedgehog (Hh) signaling pathway is associated with tumorigenesis in various tissues. In colorectal cancer (CRC), evidence for Hh activation is inconsistent, and the relationship between the Hh signaling pathway and lymphangiogenesis has not been studied. The aim of this study was to determine the relationship between Hh signaling and lymphangiogenesis and the association of this relationship with lymph node metastasis in CRC. We investigated 189 patients who underwent curative surgical resection for CRC between 2002 and 2004 at Korea University Guro Hospital. Paraffin-embedded specimens of colorectal adenocarcinoma and adjacent normal mucosa were evaluated. Immunohistochemical staining for Sonic hedgehog (Shh), Gli1, vascular endothelial growth factor C (VEGFC), and VEGF receptor 3 (VEGFR3) was performed for each specimen. Tumor specimen showed significantly strong staining of Shh, Gli1, VEGFC, and VEGFR3 compared with a normal specimen. Shh expression was not associated with Gli1 expression. Gli1 expression correlated positively with VEGFC and VEGFR3 expression (P\0.05 in both) but not with lymph node metastasis. Activation of the Hh signaling pathway associated with Gli1 promotes expression of lymphangiogenesis proteins, VEGFC and VEGFR3, in CRC. Further studies are necessary to determine the association of this relationship with lymph node metastasis in CRC. Copyright Southeastern Surgical Congress. All rights reserved.",
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T1 - Expression of GLI1 correlates with expression of lymphangiogenesis proteins, vascular endothelial growth factor c and vascular endothelial growth factor receptor 3, in colorectal cancer

AU - Hong, Kwang Dae

AU - Lee, Youngseok

AU - Kim, Baek-Hui

AU - Lee, Sun Il

AU - Moon, Hong Young

PY - 2013/2/1

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