Expression of guanylin and uroguanylin mRNA in human nasal mucosa and nasal polyps

Sang Hag Lee, Jae Pil Paeng, Hak Hyun Jung, Seung Hoon Lee, Heung Man Lee, Soon Young Kwon, Ki Jung Lim, Kwang Yoon Jung

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Objectives - Guanylin and uroguanylin are small, heat-stable peptides that were originally isolated from the small intestine and from urine, respectively. Functionally, it has been proposed that these peptides can regulate ion and water transport in various fluid-transporting epithelia. In the present study we evaluated the presence of mRNAs for human guanylin and uroguanylin in human inferior turbinate mucosa and nasal polyps. Material and Methods - The expression and localization of mRNAs for both peptides were investigated in inferior turbinate tissues and nasal polyps using reverse transcriptase polymerase chain reaction and in situ hybridization. Results - mRNAs for both peptides were detected in human turbinate mucosa and nasal polyps. In situ hybridization revealed that they were localized in the epithelial layer and submucosal glands of inferior turbinate mucosa and in the epithelial layer of nasal polyps. However, their expression was noted at low levels in the superficial epithelium of nasal polyps, compared with that of inferior turbinate mucosa. Conclusions - These results indicate that guanylin and uroguanylin in the nasal mucosa may participate in normal physiological processes, but also suggest that altered expression of these genes in nasal polyps may cause impaired electrolyte and water transport across the epithelial cells.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalActa Oto-Laryngologica
Issue number2
Publication statusPublished - 2004


  • In situ hybridization
  • Inferior turbinate
  • Nasal polyps
  • Reverse transcriptase polymerase chain reaction

ASJC Scopus subject areas

  • Otorhinolaryngology


Dive into the research topics of 'Expression of guanylin and uroguanylin mRNA in human nasal mucosa and nasal polyps'. Together they form a unique fingerprint.

Cite this