Expression of hepatocyte growth factor/c-met by RT-PCR in meningiomas

Na Rae Kim, Yang Seok Chae, Weon Jeong Lim, Seong Jin Cho

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    Background: Hepatocyte growth factor (HGF) is a potent mitogenic cytokine. C-met protein, which is known to be the HGF receptor has transmembrane tyrosine kinase activity and is encoded by the c-met oncogene. The HGF/c-met signaling pathway may play various roles in the carcinogenesis of various organs. Methods: We examined HGF and c-met mRNA expression by utilizing reverse transcription polymerase chain reaction on 40 surgically resected intracranial meningiomas (25 benign, 10 atypical, and 5 anaplastic cases). Results: An HGF overexpression was detected in 28%, 50%, and 80% of the benign, atypical and anaplastic meningiomas, respectively; a high expression of HGF or the coexpression of HGF/c-met was detected in the high grade meningiomas (the atypical and anaplastic cases, p=0.046, p=0.014). An HGF expression was statistically significant in the recurrent meningiomas (p=0.003), and HGF expression was significantly lower than c-met mRNA expression in benign meningiomas (p=0.034). Conclusions: There was no correlation between histologic subtypes and HGF/c-met expression. Determination of HGF expression can be used as a molecular predictor for recurrence of meningioimas. These results suggest that HGF and c-met expression in meningiomas may be associated with anaplastic progression.

    Original languageEnglish
    Pages (from-to)463-468
    Number of pages6
    JournalKorean Journal of Pathology
    Volume45
    Issue number5
    DOIs
    Publication statusPublished - 2011 Oct

    Keywords

    • C-met
    • Hepatocyte growth factor
    • Meningioma
    • Neoplasm recurrence, local
    • Reverse transcription polymerase chain reaction

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine

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