Expression of human β-defensin 1 mRNA in human nasal mucosa

Hag Lee Sang, Ho Lim Hyun, Man Lee Heung, Ouck Choi Jong

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Antimicrobial peptides are cationic proteins that are found in a wide range of organisms. Recent reports suggested that human β-defensin 1 (hBD- 1), a prominent group of antimicrobial peptides, is an important component of the innate immune response, particularly at mucosal surfaces that are vulnerable to colonization by potential pathogens. Therefore, hBD-1 may participate in providing intrinsic nasal mucosal defence against microbial infections. The present study aimed to look for hBD-1 mRNA in human nasal mucosa without obvious signs of inflammation. Total RNA was isolated from human inferior turbinate mucosa and hBD-1 mRNA was detected in these tissues by using reverse transcription and polymerase chain reaction (RT-PCR). By in situ hybridization, hBD-1 mRNA was predominantly localized in superficial epithelial cells and submucosal glandular epithelium of human inferior turbinate mucosa. These data suggest that nasal epithelia and submucosal glands may secrete hBD-1, contributing to the mucosal defences of the nose.

Original languageEnglish
Pages (from-to)58-61
Number of pages4
JournalActa Oto-Laryngologica
Volume120
Issue number1
DOIs
Publication statusPublished - 2000

Keywords

  • In situ hybridization
  • Inferior turbinate mucosa
  • Mucosal defence
  • RT-PCR

ASJC Scopus subject areas

  • Otorhinolaryngology

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