Expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer and their clinical significance

Woo Chul Jung, You Jin Jang, Jong Han Kim, Sung Soo Park, Seong Heum Park, Seung Joo Kim, Young Jae Mok, Chong Suk Kim

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)

    Abstract

    Purpose: Among cell adhesion molecules, serum levels of intercellular adhesion molecule-1 and E-selectin are known to be correlated with the metastatic potential of gastric cancer. In the present study, the authors investigated the expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer tissues and cultured gastric cancer cells, and examined their clinical value in gastric cancer. Materials and Methods: The protein was extracted from gastric cancer tissues and cultured gastric cancer cells (MKN-28 and Kato-III) and the expression of intercellular adhesion molecule-1 and E-selectin was examined by western blotting. The clinical significance of intercellular adhesion molecule-1 and E-selectin was explored, using immunohistochemical staining of specimens from 157 gastric cancer patients. Results: In western blot analysis, the expressions of intercellular adhesion molecule-1 in gastric cancer tissues and cultured gastric cancer cells were increased, however, E-selectin in gastric cancer tissues and cells were not increased. Among 157 gastric cancer patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and had larger tumor size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion. The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-year survival than the negative group (54.9 vs. 85.9%, respectively). Conclusions: Intercellular adhesion molecule-1 is overexpressed in gastric cancer tissues and cultured gastric cancer cells, whereas E-selectin is not overexpressed. Increased expression of intercellular adhesion molecule-1 in gastric cancer could be related to the aggressive nature of the tumor, and has a poor prognostic effect on gastric cancer.

    Original languageEnglish
    Pages (from-to)140-148
    Number of pages9
    JournalJournal of Gastric Cancer
    Volume12
    Issue number3
    DOIs
    Publication statusPublished - 2012 Sep

    Keywords

    • E-selectin
    • Intercellular adhesion molecule-1
    • Stomach neoplasms

    ASJC Scopus subject areas

    • Oncology
    • Gastroenterology
    • Cancer Research

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