Expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer and their clinical significance

Woo Chul Jung, You-Jin Jang, Jong Han Kim, Sungsoo Park, Seong-Heum Park, Seung Joo Kim, Young Jae Mok, Chong Suk Kim

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24 Citations (Scopus)

Abstract

Purpose: Among cell adhesion molecules, serum levels of intercellular adhesion molecule-1 and E-selectin are known to be correlated with the metastatic potential of gastric cancer. In the present study, the authors investigated the expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer tissues and cultured gastric cancer cells, and examined their clinical value in gastric cancer. Materials and Methods: The protein was extracted from gastric cancer tissues and cultured gastric cancer cells (MKN-28 and Kato-III) and the expression of intercellular adhesion molecule-1 and E-selectin was examined by western blotting. The clinical significance of intercellular adhesion molecule-1 and E-selectin was explored, using immunohistochemical staining of specimens from 157 gastric cancer patients. Results: In western blot analysis, the expressions of intercellular adhesion molecule-1 in gastric cancer tissues and cultured gastric cancer cells were increased, however, E-selectin in gastric cancer tissues and cells were not increased. Among 157 gastric cancer patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and had larger tumor size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion. The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-year survival than the negative group (54.9 vs. 85.9%, respectively). Conclusions: Intercellular adhesion molecule-1 is overexpressed in gastric cancer tissues and cultured gastric cancer cells, whereas E-selectin is not overexpressed. Increased expression of intercellular adhesion molecule-1 in gastric cancer could be related to the aggressive nature of the tumor, and has a poor prognostic effect on gastric cancer.

Original languageEnglish
Pages (from-to)140-148
Number of pages9
JournalJournal of Gastric Cancer
Volume12
Issue number3
DOIs
Publication statusPublished - 2012 Jan 1

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Keywords

  • E-selectin
  • Intercellular adhesion molecule-1
  • Stomach neoplasms

ASJC Scopus subject areas

  • Gastroenterology
  • Oncology
  • Cancer Research

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