Expression of liver-intestine cadherin and its correlation with lymph node metastasis in gastric cancer: Can it predict N stage preoperatively?

Sungsoo Park, Sang Hee Kang, Joong Min Park, Jong Han Kim, Sang Cheul Oh, Ju-Han Lee, Yang Seok Chae, Seung Joo Kim, Chong Suk Kim, Young Jae Mok

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Reliable method to predict lymph node metastasis is not yet available. In the present study, therefore, we examined LI-cadherin expression in human gastric cancer and attempted to find its relationship with clinicopathologic data, especially with lymph node metastasis. We also analyzed the expression in preoperative biopsy specimen to uncover its possibility of prognostication for lymph node metastasis. Methods: The paired preoperative endoscopic biopsy and postoperative resected specimens from 208 patients who had surgically been treated for gastric cancer were retrospectively analyzed immunohistochemically for expression of LI-cadherin. Results: There were 47 (22.6%) and 161 (77.4%) tumors which had positive and negative LI-cadherin expression, respectively. LI-cadherin expression was significantly correlated with tumor histology and lymph node metastasis: Furthermore, reduced expression of LI-cadherin was closely associated with tumor progression and lymph node metastasis in human gastric carcinoma. LI-cadherin expressions in both resected tumor and preoperative endoscopic tissues were found to be independent factors associated with lymph node metastasis. Conclusions: There is a close association between reduced expression of LI-cadherin and lymph node metastasis in human gastric cancer. Immunohistochemical study of LI-cadherin is relatively simple compared to sentinel node navigation surgery, and it could be a practical prediction method for lymph node metastasis in patients with this malignancy.

Original languageEnglish
Pages (from-to)94-99
Number of pages6
JournalAnnals of Surgical Oncology
Volume14
Issue number1
DOIs
Publication statusPublished - 2007 Jan 1

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Cadherins
Stomach Neoplasms
Intestines
Lymph Nodes
Neoplasm Metastasis
Liver
Neoplasms
Biopsy
Stomach
Histology
Carcinoma

Keywords

  • Gastric cancer
  • Immunohistochemisty
  • Liver-intestine cadherin
  • Lymph node metastasis

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

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title = "Expression of liver-intestine cadherin and its correlation with lymph node metastasis in gastric cancer: Can it predict N stage preoperatively?",
abstract = "Background: Reliable method to predict lymph node metastasis is not yet available. In the present study, therefore, we examined LI-cadherin expression in human gastric cancer and attempted to find its relationship with clinicopathologic data, especially with lymph node metastasis. We also analyzed the expression in preoperative biopsy specimen to uncover its possibility of prognostication for lymph node metastasis. Methods: The paired preoperative endoscopic biopsy and postoperative resected specimens from 208 patients who had surgically been treated for gastric cancer were retrospectively analyzed immunohistochemically for expression of LI-cadherin. Results: There were 47 (22.6{\%}) and 161 (77.4{\%}) tumors which had positive and negative LI-cadherin expression, respectively. LI-cadherin expression was significantly correlated with tumor histology and lymph node metastasis: Furthermore, reduced expression of LI-cadherin was closely associated with tumor progression and lymph node metastasis in human gastric carcinoma. LI-cadherin expressions in both resected tumor and preoperative endoscopic tissues were found to be independent factors associated with lymph node metastasis. Conclusions: There is a close association between reduced expression of LI-cadherin and lymph node metastasis in human gastric cancer. Immunohistochemical study of LI-cadherin is relatively simple compared to sentinel node navigation surgery, and it could be a practical prediction method for lymph node metastasis in patients with this malignancy.",
keywords = "Gastric cancer, Immunohistochemisty, Liver-intestine cadherin, Lymph node metastasis",
author = "Sungsoo Park and Kang, {Sang Hee} and Park, {Joong Min} and Kim, {Jong Han} and Oh, {Sang Cheul} and Ju-Han Lee and Chae, {Yang Seok} and Kim, {Seung Joo} and Kim, {Chong Suk} and Mok, {Young Jae}",
year = "2007",
month = "1",
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doi = "10.1245/s10434-006-9114-9",
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volume = "14",
pages = "94--99",
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TY - JOUR

T1 - Expression of liver-intestine cadherin and its correlation with lymph node metastasis in gastric cancer

T2 - Can it predict N stage preoperatively?

AU - Park, Sungsoo

AU - Kang, Sang Hee

AU - Park, Joong Min

AU - Kim, Jong Han

AU - Oh, Sang Cheul

AU - Lee, Ju-Han

AU - Chae, Yang Seok

AU - Kim, Seung Joo

AU - Kim, Chong Suk

AU - Mok, Young Jae

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Background: Reliable method to predict lymph node metastasis is not yet available. In the present study, therefore, we examined LI-cadherin expression in human gastric cancer and attempted to find its relationship with clinicopathologic data, especially with lymph node metastasis. We also analyzed the expression in preoperative biopsy specimen to uncover its possibility of prognostication for lymph node metastasis. Methods: The paired preoperative endoscopic biopsy and postoperative resected specimens from 208 patients who had surgically been treated for gastric cancer were retrospectively analyzed immunohistochemically for expression of LI-cadherin. Results: There were 47 (22.6%) and 161 (77.4%) tumors which had positive and negative LI-cadherin expression, respectively. LI-cadherin expression was significantly correlated with tumor histology and lymph node metastasis: Furthermore, reduced expression of LI-cadherin was closely associated with tumor progression and lymph node metastasis in human gastric carcinoma. LI-cadherin expressions in both resected tumor and preoperative endoscopic tissues were found to be independent factors associated with lymph node metastasis. Conclusions: There is a close association between reduced expression of LI-cadherin and lymph node metastasis in human gastric cancer. Immunohistochemical study of LI-cadherin is relatively simple compared to sentinel node navigation surgery, and it could be a practical prediction method for lymph node metastasis in patients with this malignancy.

AB - Background: Reliable method to predict lymph node metastasis is not yet available. In the present study, therefore, we examined LI-cadherin expression in human gastric cancer and attempted to find its relationship with clinicopathologic data, especially with lymph node metastasis. We also analyzed the expression in preoperative biopsy specimen to uncover its possibility of prognostication for lymph node metastasis. Methods: The paired preoperative endoscopic biopsy and postoperative resected specimens from 208 patients who had surgically been treated for gastric cancer were retrospectively analyzed immunohistochemically for expression of LI-cadherin. Results: There were 47 (22.6%) and 161 (77.4%) tumors which had positive and negative LI-cadherin expression, respectively. LI-cadherin expression was significantly correlated with tumor histology and lymph node metastasis: Furthermore, reduced expression of LI-cadherin was closely associated with tumor progression and lymph node metastasis in human gastric carcinoma. LI-cadherin expressions in both resected tumor and preoperative endoscopic tissues were found to be independent factors associated with lymph node metastasis. Conclusions: There is a close association between reduced expression of LI-cadherin and lymph node metastasis in human gastric cancer. Immunohistochemical study of LI-cadherin is relatively simple compared to sentinel node navigation surgery, and it could be a practical prediction method for lymph node metastasis in patients with this malignancy.

KW - Gastric cancer

KW - Immunohistochemisty

KW - Liver-intestine cadherin

KW - Lymph node metastasis

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