Expression of moesin and CD44 is associated with poor prognosis in gastric adenocarcinoma

Woon Yong Jung, Youngran Kang, Hyunjoo Lee, Young Jae Mok, Han Kyeom Kim, Aeree Kim, Baek-Hui Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aims: CD44 has been reported as a negative prognostic marker in gastric cancer. It interacts with moesin in epithelial-mesenchymal transition. To date, to our knowledge, there has been no clinical study dealing with the relationship between moesin and gastric adenocarcinoma. We analysed the expression of moesin and CD44 in gastric adenocarcinoma tissue, and correlations with clinicopathological factors. Methods and results: A retrospective analysis was made of 430 patients who had undergone gastrectomy at the Korea University Guro Hospital between 2002 and 2005 for gastric adenocarcinoma. Using tissue microarray and immunohistochemical staining, moesin expression was observed in 192 (44.7%) cases; it was associated significantly with poorly differentiated histology, invasion depth, lymph node metastasis, lymphatic invasion and advanced pathological TNM stage. CD44 expression was not correlated with clinicopathological features or moesin expression. Moesin expression was a strong predictor of lymph node metastasis in logistic regression analysis. Both moesin expression and CD44 expression were associated significantly with poor overall survival in univariate analysis. Furthermore, in multivariate analysis, moesin and CD44 were independent markers of poor prognosis, along with pathological TNM stage and older patient age. Conclusion: Moesin expression and CD44 expression might be useful markers of poor prognosis in gastric adenocarcinoma.

Original languageEnglish
Pages (from-to)474-481
Number of pages8
JournalHistopathology
Volume63
Issue number4
DOIs
Publication statusPublished - 2013 Oct 1

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Stomach
Adenocarcinoma
Lymph Nodes
Lymphatic Metastasis
moesin
Epithelial-Mesenchymal Transition
Gastrectomy
Korea
Stomach Neoplasms
Histology
Multivariate Analysis
Logistic Models
Regression Analysis
Staining and Labeling
Neoplasm Metastasis
Survival

Keywords

  • Adenocarcinoma
  • CD44
  • Epithelial-mesenchymal transition
  • Moesin
  • Stomach

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Expression of moesin and CD44 is associated with poor prognosis in gastric adenocarcinoma. / Jung, Woon Yong; Kang, Youngran; Lee, Hyunjoo; Mok, Young Jae; Kim, Han Kyeom; Kim, Aeree; Kim, Baek-Hui.

In: Histopathology, Vol. 63, No. 4, 01.10.2013, p. 474-481.

Research output: Contribution to journalArticle

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AU - Kim, Han Kyeom

AU - Kim, Aeree

AU - Kim, Baek-Hui

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N2 - Aims: CD44 has been reported as a negative prognostic marker in gastric cancer. It interacts with moesin in epithelial-mesenchymal transition. To date, to our knowledge, there has been no clinical study dealing with the relationship between moesin and gastric adenocarcinoma. We analysed the expression of moesin and CD44 in gastric adenocarcinoma tissue, and correlations with clinicopathological factors. Methods and results: A retrospective analysis was made of 430 patients who had undergone gastrectomy at the Korea University Guro Hospital between 2002 and 2005 for gastric adenocarcinoma. Using tissue microarray and immunohistochemical staining, moesin expression was observed in 192 (44.7%) cases; it was associated significantly with poorly differentiated histology, invasion depth, lymph node metastasis, lymphatic invasion and advanced pathological TNM stage. CD44 expression was not correlated with clinicopathological features or moesin expression. Moesin expression was a strong predictor of lymph node metastasis in logistic regression analysis. Both moesin expression and CD44 expression were associated significantly with poor overall survival in univariate analysis. Furthermore, in multivariate analysis, moesin and CD44 were independent markers of poor prognosis, along with pathological TNM stage and older patient age. Conclusion: Moesin expression and CD44 expression might be useful markers of poor prognosis in gastric adenocarcinoma.

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