Expression of mRNA of trefoil factor peptides in human nasal mucosa

Hag Lee See Hag Lee, Seung Hoon Lee, Hoon Oh Byung Hoon Oh, Man Lee Heung Man Lee, Ouck Choi Jong Ouck Choi, Kwang-Yoon Jung

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Trefoil factor family (TFF) peptides are typical secretory products of gastrointestinal mucus epithelia. Three TFF peptides exist in humans, TFF1 (formerly pS2), TFF2 (formerly hSP) and TFF3 (formerly hP1B/hITF), acting as link peptides and influencing the rheological properties of mucous gels. The combined actions of TFF peptides and mucins have been shown to provide significant protection to mucosal surfaces. In this respect, TFF peptides may play a key role in the maintenance of the surface integrity of nasal mucosa. The present study aimed to investigate the expression of mRNA of TFF peptides in human inferior turbinate mucosa using reverse transcription polymerase chain reaction and in situ hybridization. TFF1 and TFF3 mRNA were detected in the human turbinate tissues examined. In contrast, TFF2 mRNA was not expressed in any samples. Using in situ hybridization, TFF1 and TFF3 mRNA were predominantly localized in epithelial cells and submucosal glandular epithelium. These data suggest that nasal epithelia and submucosal glands may secrete TFF1 and TFF3, contributing to the stabilization of the mucous lining of human nasal mucosa.

Original languageEnglish
Pages (from-to)849-853
Number of pages5
JournalActa Oto-Laryngologica
Volume121
Issue number7
DOIs
Publication statusPublished - 2001 Nov 27

Fingerprint

Nasal Mucosa
Messenger RNA
Turbinates
In Situ Hybridization
Epithelium
Mucins
Mucus
Reverse Transcription
Mucous Membrane
Gels
Epithelial Cells
Maintenance
Trefoil Factors
Polymerase Chain Reaction
Peptides

Keywords

  • Inferior turbinate mucosa
  • TFF1
  • TFF3

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

See Hag Lee, H. L., Lee, S. H., Byung Hoon Oh, H. O., Heung Man Lee, M. L., Jong Ouck Choi, O. C., & Jung, K-Y. (2001). Expression of mRNA of trefoil factor peptides in human nasal mucosa. Acta Oto-Laryngologica, 121(7), 849-853. https://doi.org/10.1080/00016480152602320

Expression of mRNA of trefoil factor peptides in human nasal mucosa. / See Hag Lee, Hag Lee; Lee, Seung Hoon; Byung Hoon Oh, Hoon Oh; Heung Man Lee, Man Lee; Jong Ouck Choi, Ouck Choi; Jung, Kwang-Yoon.

In: Acta Oto-Laryngologica, Vol. 121, No. 7, 27.11.2001, p. 849-853.

Research output: Contribution to journalArticle

See Hag Lee, HL, Lee, SH, Byung Hoon Oh, HO, Heung Man Lee, ML, Jong Ouck Choi, OC & Jung, K-Y 2001, 'Expression of mRNA of trefoil factor peptides in human nasal mucosa', Acta Oto-Laryngologica, vol. 121, no. 7, pp. 849-853. https://doi.org/10.1080/00016480152602320
See Hag Lee HL, Lee SH, Byung Hoon Oh HO, Heung Man Lee ML, Jong Ouck Choi OC, Jung K-Y. Expression of mRNA of trefoil factor peptides in human nasal mucosa. Acta Oto-Laryngologica. 2001 Nov 27;121(7):849-853. https://doi.org/10.1080/00016480152602320
See Hag Lee, Hag Lee ; Lee, Seung Hoon ; Byung Hoon Oh, Hoon Oh ; Heung Man Lee, Man Lee ; Jong Ouck Choi, Ouck Choi ; Jung, Kwang-Yoon. / Expression of mRNA of trefoil factor peptides in human nasal mucosa. In: Acta Oto-Laryngologica. 2001 ; Vol. 121, No. 7. pp. 849-853.
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