Expression of Mucin Genes in Chronic Ethmoiditis

Hak Hyun Jung; Je Hyuck Lee; Young Tae Kim; Sang Duck Lee; Jae Hoon Park

doi:10.2500/105065800782102690

Expression of Mucin Genes in Chronic Ethmoiditis

Hak Hyun Jung, Je Hyuck Lee, Young Tae Kim, Sang Duck Lee, Jae Hoon Park

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

We have investigated the profiles of MUC genes expressed in chronic ethmoiditis mucosa and normal ethmoid mucosa using RT-PCR, and the morphology of chronic ethmoiditis by a combination of light and electron microscope was observed. In the light- and electron-microscopic studies, chronic ethmoiditis mucosa revealed increased numbers of goblet cells with higher production of mucus in comparison to normal ethmoid mucosa. RT-PCR of cDNAs from three normal ethmoid mucosa revealed the same pattern of mucin gene expression, such as MUC5AC and MUC8. However, RT-PCR of cDNAs from eight chronic ethmoiditis mucosa showed the expression of two MUC1, six MUC4, eight MUC5AC, five MUC5B, seven MUC7, and eight MUC8, MUC2 and MUC6 were not detected. These results suggest that MUC4, MUC5AC, MUC5B, MUC7, and MUC8 are major mucins in the ethmoid mucosa and are up-regulated by chronic inflammation.

Original language	English
Pages (from-to)	163-170
Number of pages	8
Journal	American Journal of Rhinology
Volume	14
Issue number	3
DOIs	https://doi.org/10.2500/105065800782102690
Publication status	Published - 2000

ASJC Scopus subject areas

Otorhinolaryngology

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title = "Expression of Mucin Genes in Chronic Ethmoiditis",

abstract = "We have investigated the profiles of MUC genes expressed in chronic ethmoiditis mucosa and normal ethmoid mucosa using RT-PCR, and the morphology of chronic ethmoiditis by a combination of light and electron microscope was observed. In the light- and electron-microscopic studies, chronic ethmoiditis mucosa revealed increased numbers of goblet cells with higher production of mucus in comparison to normal ethmoid mucosa. RT-PCR of cDNAs from three normal ethmoid mucosa revealed the same pattern of mucin gene expression, such as MUC5AC and MUC8. However, RT-PCR of cDNAs from eight chronic ethmoiditis mucosa showed the expression of two MUC1, six MUC4, eight MUC5AC, five MUC5B, seven MUC7, and eight MUC8, MUC2 and MUC6 were not detected. These results suggest that MUC4, MUC5AC, MUC5B, MUC7, and MUC8 are major mucins in the ethmoid mucosa and are up-regulated by chronic inflammation.",

author = "Jung, {Hak Hyun} and Lee, {Je Hyuck} and Kim, {Young Tae} and Lee, {Sang Duck} and Park, {Jae Hoon}",

year = "2000",

doi = "10.2500/105065800782102690",

language = "English",

volume = "14",

pages = "163--170",

journal = "American Journal of Rhinology and Allergy",

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T1 - Expression of Mucin Genes in Chronic Ethmoiditis

AU - Jung, Hak Hyun

AU - Lee, Je Hyuck

AU - Kim, Young Tae

AU - Lee, Sang Duck

AU - Park, Jae Hoon

PY - 2000

Y1 - 2000

N2 - We have investigated the profiles of MUC genes expressed in chronic ethmoiditis mucosa and normal ethmoid mucosa using RT-PCR, and the morphology of chronic ethmoiditis by a combination of light and electron microscope was observed. In the light- and electron-microscopic studies, chronic ethmoiditis mucosa revealed increased numbers of goblet cells with higher production of mucus in comparison to normal ethmoid mucosa. RT-PCR of cDNAs from three normal ethmoid mucosa revealed the same pattern of mucin gene expression, such as MUC5AC and MUC8. However, RT-PCR of cDNAs from eight chronic ethmoiditis mucosa showed the expression of two MUC1, six MUC4, eight MUC5AC, five MUC5B, seven MUC7, and eight MUC8, MUC2 and MUC6 were not detected. These results suggest that MUC4, MUC5AC, MUC5B, MUC7, and MUC8 are major mucins in the ethmoid mucosa and are up-regulated by chronic inflammation.

AB - We have investigated the profiles of MUC genes expressed in chronic ethmoiditis mucosa and normal ethmoid mucosa using RT-PCR, and the morphology of chronic ethmoiditis by a combination of light and electron microscope was observed. In the light- and electron-microscopic studies, chronic ethmoiditis mucosa revealed increased numbers of goblet cells with higher production of mucus in comparison to normal ethmoid mucosa. RT-PCR of cDNAs from three normal ethmoid mucosa revealed the same pattern of mucin gene expression, such as MUC5AC and MUC8. However, RT-PCR of cDNAs from eight chronic ethmoiditis mucosa showed the expression of two MUC1, six MUC4, eight MUC5AC, five MUC5B, seven MUC7, and eight MUC8, MUC2 and MUC6 were not detected. These results suggest that MUC4, MUC5AC, MUC5B, MUC7, and MUC8 are major mucins in the ethmoid mucosa and are up-regulated by chronic inflammation.

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DO - 10.2500/105065800782102690

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JO - American Journal of Rhinology and Allergy

JF - American Journal of Rhinology and Allergy

SN - 1945-8924

IS - 3

ER -

Expression of Mucin Genes in Chronic Ethmoiditis

Abstract

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