Expression of Mucin Genes in Chronic Ethmoiditis

Hak Hyun Jung, Je Hyuck Lee, Young Tae Kim, Sang Duck Lee, Jae Hoon Park

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)

    Abstract

    We have investigated the profiles of MUC genes expressed in chronic ethmoiditis mucosa and normal ethmoid mucosa using RT-PCR, and the morphology of chronic ethmoiditis by a combination of light and electron microscope was observed. In the light- and electron-microscopic studies, chronic ethmoiditis mucosa revealed increased numbers of goblet cells with higher production of mucus in comparison to normal ethmoid mucosa. RT-PCR of cDNAs from three normal ethmoid mucosa revealed the same pattern of mucin gene expression, such as MUC5AC and MUC8. However, RT-PCR of cDNAs from eight chronic ethmoiditis mucosa showed the expression of two MUC1, six MUC4, eight MUC5AC, five MUC5B, seven MUC7, and eight MUC8, MUC2 and MUC6 were not detected. These results suggest that MUC4, MUC5AC, MUC5B, MUC7, and MUC8 are major mucins in the ethmoid mucosa and are up-regulated by chronic inflammation.

    Original languageEnglish
    Pages (from-to)163-170
    Number of pages8
    JournalAmerican Journal of Rhinology
    Volume14
    Issue number3
    DOIs
    Publication statusPublished - 2000

    ASJC Scopus subject areas

    • Otorhinolaryngology

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