Expression of osteopontin and clusterin in transitional cell carcinoma of the bladder: Comparison to the pathologic stage

Jong Hyun Yoon, Ju Han Lee, Bum Woo Yeom, Nam Hee Won, Duck Ki Yoon

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    Purpose: This study was performed to evaluate the expressions of osteopontin (OPN) and clusterin in a transitional cell carcinoma (TCC) of the urinary bladder, and then compare their expression rates with the tumor invasiveness. Materials and methods: Twenty-five superficial and 25 invasive TCC were used for immunohistochemical staining. Results: All 25 non-invasive TCC showed a strong positive reaction for OPN. Twenty of the invasive TCC showed a strong positive reaction for OPN, but 5 showed only a weak positive reaction. OPN expression was significantly decreased in the invasive TCC (p=0.02). Eighteen superficial TCC showed a weak positive reaction for clusterin, with 7 showing a negative reaction. Nine invasive TCC showed a strong positive reaction for clusterin, and 11 showed only a weak positive reaction. Five invasive TCC showed a negative reaction for clusterin. Clusterin expression was significantly increased in the invasive TCC (p=0.001). Conclusions: These results may suggest that OPN and clusterin could be used as markers to predict the biological behavior of a TCC.

    Original languageEnglish
    Pages (from-to)341-346
    Number of pages6
    JournalKorean Journal of Urology
    Volume46
    Issue number4
    Publication statusPublished - 2005 Apr

    Keywords

    • Bladder
    • Clusterin
    • Osteopontin
    • Transitional cell carcinoma

    ASJC Scopus subject areas

    • Urology

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