Expression of osteopontin and clusterin in transitional cell carcinoma of the bladder

Comparison to the pathologic stage

Jong Hyun Yoon, Ju-Han Lee, Bum Woo Yeom, Nam Hee Won, Duck Ki Yoon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: This study was performed to evaluate the expressions of osteopontin (OPN) and clusterin in a transitional cell carcinoma (TCC) of the urinary bladder, and then compare their expression rates with the tumor invasiveness. Materials and methods: Twenty-five superficial and 25 invasive TCC were used for immunohistochemical staining. Results: All 25 non-invasive TCC showed a strong positive reaction for OPN. Twenty of the invasive TCC showed a strong positive reaction for OPN, but 5 showed only a weak positive reaction. OPN expression was significantly decreased in the invasive TCC (p=0.02). Eighteen superficial TCC showed a weak positive reaction for clusterin, with 7 showing a negative reaction. Nine invasive TCC showed a strong positive reaction for clusterin, and 11 showed only a weak positive reaction. Five invasive TCC showed a negative reaction for clusterin. Clusterin expression was significantly increased in the invasive TCC (p=0.001). Conclusions: These results may suggest that OPN and clusterin could be used as markers to predict the biological behavior of a TCC.

Original languageEnglish
Pages (from-to)341-346
Number of pages6
JournalKorean Journal of Urology
Volume46
Issue number4
Publication statusPublished - 2005 Apr 1

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Clusterin
Osteopontin
Transitional Cell Carcinoma
Urinary Bladder

Keywords

  • Bladder
  • Clusterin
  • Osteopontin
  • Transitional cell carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

Expression of osteopontin and clusterin in transitional cell carcinoma of the bladder : Comparison to the pathologic stage. / Yoon, Jong Hyun; Lee, Ju-Han; Yeom, Bum Woo; Won, Nam Hee; Yoon, Duck Ki.

In: Korean Journal of Urology, Vol. 46, No. 4, 01.04.2005, p. 341-346.

Research output: Contribution to journalArticle

Yoon, Jong Hyun ; Lee, Ju-Han ; Yeom, Bum Woo ; Won, Nam Hee ; Yoon, Duck Ki. / Expression of osteopontin and clusterin in transitional cell carcinoma of the bladder : Comparison to the pathologic stage. In: Korean Journal of Urology. 2005 ; Vol. 46, No. 4. pp. 341-346.
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