Expression of p16, Rb and FHIT proteins in urothelial carcinoma of the urinary bladder

Sun Hee Han, Ju-Han Lee, Seo Hee Kim, Jungsuk An, Eung Seok Lee, Young Sik Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The goal of this study was to investigate the expression of p16, retinoblastoma (Rb) and fragile histidine triad (FHIT) proteins in urothelial carcinomas of the urinary bladder, and to evaluate the relationship between clinicopathlogic parameters and each protein expression level. Methods: The expression of p16, Rb, and FHIT proteins were studied in 176 patients with urothelial carcinoma of the urinary bladder by immunohistochemistry. Results: The diffuse positive expression of the p16 protein was significantly associated with high grade and advanced tumor depth (p=0.007 and p=0.020). The loss of the Rb protein was significantly associated with old age and disease recurrence (p=0.020 and 0.037). The loss of the FHIT protein was significantly associated with advanced tumor depth (p=0.002). Conclusions: Our data suggest that p16 and FHIT proteins may be involved in the progression of urothelial carcinoma. In addition, p16 may be a useful prognostic marker for individual urothelial carcinoma patients.

Original languageEnglish
Pages (from-to)294-298
Number of pages5
JournalKorean Journal of Pathology
Volume42
Issue number5
Publication statusPublished - 2008 Dec 1

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Retinoblastoma
Urinary Bladder
Carcinoma
Retinoblastoma Protein
Neoplasms
Proteins
Immunohistochemistry
Recurrence
fragile histidine triad protein

Keywords

  • Bladder cancer
  • FHIT protein
  • P16INK4A protein
  • Retinoblastoma protein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Expression of p16, Rb and FHIT proteins in urothelial carcinoma of the urinary bladder. / Han, Sun Hee; Lee, Ju-Han; Kim, Seo Hee; An, Jungsuk; Lee, Eung Seok; Kim, Young Sik.

In: Korean Journal of Pathology, Vol. 42, No. 5, 01.12.2008, p. 294-298.

Research output: Contribution to journalArticle

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AU - Han, Sun Hee

AU - Lee, Ju-Han

AU - Kim, Seo Hee

AU - An, Jungsuk

AU - Lee, Eung Seok

AU - Kim, Young Sik

PY - 2008/12/1

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N2 - Background: The goal of this study was to investigate the expression of p16, retinoblastoma (Rb) and fragile histidine triad (FHIT) proteins in urothelial carcinomas of the urinary bladder, and to evaluate the relationship between clinicopathlogic parameters and each protein expression level. Methods: The expression of p16, Rb, and FHIT proteins were studied in 176 patients with urothelial carcinoma of the urinary bladder by immunohistochemistry. Results: The diffuse positive expression of the p16 protein was significantly associated with high grade and advanced tumor depth (p=0.007 and p=0.020). The loss of the Rb protein was significantly associated with old age and disease recurrence (p=0.020 and 0.037). The loss of the FHIT protein was significantly associated with advanced tumor depth (p=0.002). Conclusions: Our data suggest that p16 and FHIT proteins may be involved in the progression of urothelial carcinoma. In addition, p16 may be a useful prognostic marker for individual urothelial carcinoma patients.

AB - Background: The goal of this study was to investigate the expression of p16, retinoblastoma (Rb) and fragile histidine triad (FHIT) proteins in urothelial carcinomas of the urinary bladder, and to evaluate the relationship between clinicopathlogic parameters and each protein expression level. Methods: The expression of p16, Rb, and FHIT proteins were studied in 176 patients with urothelial carcinoma of the urinary bladder by immunohistochemistry. Results: The diffuse positive expression of the p16 protein was significantly associated with high grade and advanced tumor depth (p=0.007 and p=0.020). The loss of the Rb protein was significantly associated with old age and disease recurrence (p=0.020 and 0.037). The loss of the FHIT protein was significantly associated with advanced tumor depth (p=0.002). Conclusions: Our data suggest that p16 and FHIT proteins may be involved in the progression of urothelial carcinoma. In addition, p16 may be a useful prognostic marker for individual urothelial carcinoma patients.

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