Expression of protein S100A4 is a predictor of recurrence in colorectal cancer

Jung Myun Kwak, Hyun Joo Lee, Seon Hahn Kim, Han Kyeom Kim, Young Jae Mok, Young Tae Park, Jong Sang Choi, Hong Young Moon

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


AIM: To investigate the prognostic significance of S100A4 expression in colorectal cancer and its correlation with expression of E-cadherin and p53. METHODS: A cohort of archival formalin-fixed paraffinembedded specimens was selected from 127 patients with colorectal cancer who underwent surgical resection between April 2000 and March 2004 at the Department of Surgery, Korea University Guro Hospital. The expression of protein S100A4 was evaluated according to the proportion of positively stained cancer cells. In each case, three core biopsies with a diameter of 2 mm were punched out and positioned in a recipient paraffin array block. Four-μm sections of these tissue array blocks were used for immunohistochemical analysis of protein S100A4, E-cadherin, and p53. Clinicopathological data were based on the original histopathologic reports and clinical records of patients. RESULTS: In normal colorectal mucosa, protein S100A4 immunoreactivity was clearly absent in both cytoplasm and nucleus. However, positive immunoreactivity of protein S100A4 was detected in 45 (35.4%) of the tumor cases. There was no significant association between positive immunoreactivity of protein S100A4 and clinicopathological parameters such as tumor differentiation or TNM stage, and also no correlation between the reactivity and E-cadherin or p53 expression. However, positive immunoreactivity of protein S100A4 was found to be associated with tumor recurrence (P = 0.004), and was also associated with significantly worse overall survival in the Kaplan-Meyer survival analysis (P = 0.044). After adjustment for tumor differentiation, tumor depth and nodal status, however, it failed to achieve statistical significance (P = 0.067). CONCLUSION: The expression of protein S100A4 is associated with tumor recurrence and poor overall survival in patients with colorectal cancer.

Original languageEnglish
Pages (from-to)3897-3904
Number of pages8
JournalWorld journal of gastroenterology
Issue number31
Publication statusPublished - 2010 Aug 21
Externally publishedYes


  • Colorectal cancer
  • E-cadherin
  • Prognostic factor
  • S100A4
  • p53

ASJC Scopus subject areas

  • Gastroenterology


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