Expression of ROR1, pAkt, and pCREB in gastric adenocarcinoma

Hyeyoon Chang, Woon Yong Jung, Youngran Kang, Hyunjoo Lee, Aeree Kim, Baek-Hui Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a transmembrane protein of receptor tyrosine kinase family. High expression of ROR1 is reported in many types of malignancies and is thought to be involved in tumor growth, apoptosis, and epithelial-mesenchymal transition. In this study, we examined the expression of ROR1, pAkt, and pCREB in gastric adenocarcinoma and analyzed with clinicopathologic factors and tumor proliferation. Tissue microarray blocks containing 424 gastric adenocarcinomas were used for immunohistochemical staining. Ki-67 labeling index was used for tumor proliferation activity. High expression of ROR1 (63%), pAkt (36%), and pCREB (20%) was observed in gastric adenocarcinomas, and expression of these proteins was well intercorrelated. ROR1 and pCREB expression was associated with Ki-67 labeling index (P <.001). Expression of pAkt and pCREB group showed longer survival in univariate analysis (P =.007 and P <.001, respectively). This is the first study that analyzed ROR1 expression in gastric adenocarcinoma tissue samples. We revealed that gastric adenocarcinomas highly express ROR1 and related proteins and its prognostic significance. ROR1 in gastric adenocarcinoma could be possible candidate of therapeutic target, and more comprehensive study is required.

Original languageEnglish
Pages (from-to)330-334
Number of pages5
JournalAnnals of Diagnostic Pathology
Volume19
Issue number5
DOIs
Publication statusPublished - 2015 Oct 1

Fingerprint

Stomach
Adenocarcinoma
Receptor Tyrosine Kinase-like Orphan Receptors
Neoplasms
Epithelial-Mesenchymal Transition
Receptor Protein-Tyrosine Kinases
Proteins
Apoptosis
Staining and Labeling
Growth
Therapeutics

Keywords

  • Adenocarcinoma
  • Akt
  • CREB
  • ROR1
  • Stomach

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Expression of ROR1, pAkt, and pCREB in gastric adenocarcinoma. / Chang, Hyeyoon; Jung, Woon Yong; Kang, Youngran; Lee, Hyunjoo; Kim, Aeree; Kim, Baek-Hui.

In: Annals of Diagnostic Pathology, Vol. 19, No. 5, 01.10.2015, p. 330-334.

Research output: Contribution to journalArticle

Chang, Hyeyoon ; Jung, Woon Yong ; Kang, Youngran ; Lee, Hyunjoo ; Kim, Aeree ; Kim, Baek-Hui. / Expression of ROR1, pAkt, and pCREB in gastric adenocarcinoma. In: Annals of Diagnostic Pathology. 2015 ; Vol. 19, No. 5. pp. 330-334.
@article{b46024c7408e4f849655742b37272133,
title = "Expression of ROR1, pAkt, and pCREB in gastric adenocarcinoma",
abstract = "The receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a transmembrane protein of receptor tyrosine kinase family. High expression of ROR1 is reported in many types of malignancies and is thought to be involved in tumor growth, apoptosis, and epithelial-mesenchymal transition. In this study, we examined the expression of ROR1, pAkt, and pCREB in gastric adenocarcinoma and analyzed with clinicopathologic factors and tumor proliferation. Tissue microarray blocks containing 424 gastric adenocarcinomas were used for immunohistochemical staining. Ki-67 labeling index was used for tumor proliferation activity. High expression of ROR1 (63{\%}), pAkt (36{\%}), and pCREB (20{\%}) was observed in gastric adenocarcinomas, and expression of these proteins was well intercorrelated. ROR1 and pCREB expression was associated with Ki-67 labeling index (P <.001). Expression of pAkt and pCREB group showed longer survival in univariate analysis (P =.007 and P <.001, respectively). This is the first study that analyzed ROR1 expression in gastric adenocarcinoma tissue samples. We revealed that gastric adenocarcinomas highly express ROR1 and related proteins and its prognostic significance. ROR1 in gastric adenocarcinoma could be possible candidate of therapeutic target, and more comprehensive study is required.",
keywords = "Adenocarcinoma, Akt, CREB, ROR1, Stomach",
author = "Hyeyoon Chang and Jung, {Woon Yong} and Youngran Kang and Hyunjoo Lee and Aeree Kim and Baek-Hui Kim",
year = "2015",
month = "10",
day = "1",
doi = "10.1016/j.anndiagpath.2015.06.010",
language = "English",
volume = "19",
pages = "330--334",
journal = "Annals of Diagnostic Pathology",
issn = "1092-9134",
publisher = "W.B. Saunders Ltd",
number = "5",

}

TY - JOUR

T1 - Expression of ROR1, pAkt, and pCREB in gastric adenocarcinoma

AU - Chang, Hyeyoon

AU - Jung, Woon Yong

AU - Kang, Youngran

AU - Lee, Hyunjoo

AU - Kim, Aeree

AU - Kim, Baek-Hui

PY - 2015/10/1

Y1 - 2015/10/1

N2 - The receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a transmembrane protein of receptor tyrosine kinase family. High expression of ROR1 is reported in many types of malignancies and is thought to be involved in tumor growth, apoptosis, and epithelial-mesenchymal transition. In this study, we examined the expression of ROR1, pAkt, and pCREB in gastric adenocarcinoma and analyzed with clinicopathologic factors and tumor proliferation. Tissue microarray blocks containing 424 gastric adenocarcinomas were used for immunohistochemical staining. Ki-67 labeling index was used for tumor proliferation activity. High expression of ROR1 (63%), pAkt (36%), and pCREB (20%) was observed in gastric adenocarcinomas, and expression of these proteins was well intercorrelated. ROR1 and pCREB expression was associated with Ki-67 labeling index (P <.001). Expression of pAkt and pCREB group showed longer survival in univariate analysis (P =.007 and P <.001, respectively). This is the first study that analyzed ROR1 expression in gastric adenocarcinoma tissue samples. We revealed that gastric adenocarcinomas highly express ROR1 and related proteins and its prognostic significance. ROR1 in gastric adenocarcinoma could be possible candidate of therapeutic target, and more comprehensive study is required.

AB - The receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a transmembrane protein of receptor tyrosine kinase family. High expression of ROR1 is reported in many types of malignancies and is thought to be involved in tumor growth, apoptosis, and epithelial-mesenchymal transition. In this study, we examined the expression of ROR1, pAkt, and pCREB in gastric adenocarcinoma and analyzed with clinicopathologic factors and tumor proliferation. Tissue microarray blocks containing 424 gastric adenocarcinomas were used for immunohistochemical staining. Ki-67 labeling index was used for tumor proliferation activity. High expression of ROR1 (63%), pAkt (36%), and pCREB (20%) was observed in gastric adenocarcinomas, and expression of these proteins was well intercorrelated. ROR1 and pCREB expression was associated with Ki-67 labeling index (P <.001). Expression of pAkt and pCREB group showed longer survival in univariate analysis (P =.007 and P <.001, respectively). This is the first study that analyzed ROR1 expression in gastric adenocarcinoma tissue samples. We revealed that gastric adenocarcinomas highly express ROR1 and related proteins and its prognostic significance. ROR1 in gastric adenocarcinoma could be possible candidate of therapeutic target, and more comprehensive study is required.

KW - Adenocarcinoma

KW - Akt

KW - CREB

KW - ROR1

KW - Stomach

UR - http://www.scopus.com/inward/record.url?scp=84941599335&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941599335&partnerID=8YFLogxK

U2 - 10.1016/j.anndiagpath.2015.06.010

DO - 10.1016/j.anndiagpath.2015.06.010

M3 - Article

C2 - 26245996

AN - SCOPUS:84941599335

VL - 19

SP - 330

EP - 334

JO - Annals of Diagnostic Pathology

JF - Annals of Diagnostic Pathology

SN - 1092-9134

IS - 5

ER -