Abstract
Background: Sirtuin 1 (SIRT1) and deleted in breast cancer 1 (DBC1) are known as tumor suppressor or promoter genes. This may be due to their diverse functions and interaction with other proteins. Gastric adenocarcinoma is one of the most common malignancies, but little is known about its carcinogenesis. Therefore, we investigated the association of immunohistochemical expression of SIRT1, DBC1, p53, and β-catenin and their variable clinicopathological characteristics. Methods: We obtained samples from 452 patients who underwent gastrectomy. Tissue microarray blocks were constructed and immonohistochemical staining was performed. Results: Expression of DBC1 and SIRT1 was associated with lower histologic grade, intestinal type of Lauren classification, and lower pT (p<0.001) and pN stage (DBC1, p=0.002; SIRT1, p<0.001). Association between absence of lymphatic invasion, and SIRT1 (p=0.001) and DBC1 (p=0.004) was observed. Cytoplasmic β-catenin expression was associated with lower histologic grade, pT, pN, tumor-node-metastasis (TNM) stage, DBC1 (p<0.001), and SIRT1 (p=0.001). Expression of SIRT1 and DBC1 was not associated with p53 (p=0.063 and p=0.060). DBC1 was an independent good prognostic factor in multivariate analysis (p=0.012). Conclusions: SIRC1 and DBC1 can be considered to be good prognostic factors in gastric adenocarcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 523-531 |
| Number of pages | 9 |
| Journal | Korean Journal of Pathology |
| Volume | 46 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2012 Dec 1 |
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Keywords
- Adenocarcinoma
- DBC1 protein
- Human
- SIRT1 protein
- Stomach
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Expression of SIRT1 and DBC1 in gastric adenocarcinoma. / Kang, Youngran; Jung, Woon Yong; Lee, Hyunjoo; Kim, Eunjung Lee Aeree; Kim, Baek-Hui.
In: Korean Journal of Pathology, Vol. 46, No. 6, 01.12.2012, p. 523-531.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of SIRT1 and DBC1 in gastric adenocarcinoma
AU - Kang, Youngran
AU - Jung, Woon Yong
AU - Lee, Hyunjoo
AU - Kim, Eunjung Lee Aeree
AU - Kim, Baek-Hui
PY - 2012/12/1
Y1 - 2012/12/1
N2 - Background: Sirtuin 1 (SIRT1) and deleted in breast cancer 1 (DBC1) are known as tumor suppressor or promoter genes. This may be due to their diverse functions and interaction with other proteins. Gastric adenocarcinoma is one of the most common malignancies, but little is known about its carcinogenesis. Therefore, we investigated the association of immunohistochemical expression of SIRT1, DBC1, p53, and β-catenin and their variable clinicopathological characteristics. Methods: We obtained samples from 452 patients who underwent gastrectomy. Tissue microarray blocks were constructed and immonohistochemical staining was performed. Results: Expression of DBC1 and SIRT1 was associated with lower histologic grade, intestinal type of Lauren classification, and lower pT (p<0.001) and pN stage (DBC1, p=0.002; SIRT1, p<0.001). Association between absence of lymphatic invasion, and SIRT1 (p=0.001) and DBC1 (p=0.004) was observed. Cytoplasmic β-catenin expression was associated with lower histologic grade, pT, pN, tumor-node-metastasis (TNM) stage, DBC1 (p<0.001), and SIRT1 (p=0.001). Expression of SIRT1 and DBC1 was not associated with p53 (p=0.063 and p=0.060). DBC1 was an independent good prognostic factor in multivariate analysis (p=0.012). Conclusions: SIRC1 and DBC1 can be considered to be good prognostic factors in gastric adenocarcinoma.
AB - Background: Sirtuin 1 (SIRT1) and deleted in breast cancer 1 (DBC1) are known as tumor suppressor or promoter genes. This may be due to their diverse functions and interaction with other proteins. Gastric adenocarcinoma is one of the most common malignancies, but little is known about its carcinogenesis. Therefore, we investigated the association of immunohistochemical expression of SIRT1, DBC1, p53, and β-catenin and their variable clinicopathological characteristics. Methods: We obtained samples from 452 patients who underwent gastrectomy. Tissue microarray blocks were constructed and immonohistochemical staining was performed. Results: Expression of DBC1 and SIRT1 was associated with lower histologic grade, intestinal type of Lauren classification, and lower pT (p<0.001) and pN stage (DBC1, p=0.002; SIRT1, p<0.001). Association between absence of lymphatic invasion, and SIRT1 (p=0.001) and DBC1 (p=0.004) was observed. Cytoplasmic β-catenin expression was associated with lower histologic grade, pT, pN, tumor-node-metastasis (TNM) stage, DBC1 (p<0.001), and SIRT1 (p=0.001). Expression of SIRT1 and DBC1 was not associated with p53 (p=0.063 and p=0.060). DBC1 was an independent good prognostic factor in multivariate analysis (p=0.012). Conclusions: SIRC1 and DBC1 can be considered to be good prognostic factors in gastric adenocarcinoma.
KW - Adenocarcinoma
KW - DBC1 protein
KW - Human
KW - SIRT1 protein
KW - Stomach
UR - http://www.scopus.com/inward/record.url?scp=84874038890&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874038890&partnerID=8YFLogxK
U2 - 10.4132/KoreanJPathol.2012.46.6.523
DO - 10.4132/KoreanJPathol.2012.46.6.523
M3 - Article
VL - 46
SP - 523
EP - 531
JO - Journal of Pathology and Translational Medicine
JF - Journal of Pathology and Translational Medicine
SN - 2383-7837
IS - 6
ER -