Expression of SIRT1 and DBC1 in gastric adenocarcinoma

Youngran Kang, Woon Yong Jung, Hyunjoo Lee, Eunjung Lee Aeree Kim, Baek Hui Kim

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)

    Abstract

    Background: Sirtuin 1 (SIRT1) and deleted in breast cancer 1 (DBC1) are known as tumor suppressor or promoter genes. This may be due to their diverse functions and interaction with other proteins. Gastric adenocarcinoma is one of the most common malignancies, but little is known about its carcinogenesis. Therefore, we investigated the association of immunohistochemical expression of SIRT1, DBC1, p53, and β-catenin and their variable clinicopathological characteristics. Methods: We obtained samples from 452 patients who underwent gastrectomy. Tissue microarray blocks were constructed and immonohistochemical staining was performed. Results: Expression of DBC1 and SIRT1 was associated with lower histologic grade, intestinal type of Lauren classification, and lower pT (p<0.001) and pN stage (DBC1, p=0.002; SIRT1, p<0.001). Association between absence of lymphatic invasion, and SIRT1 (p=0.001) and DBC1 (p=0.004) was observed. Cytoplasmic β-catenin expression was associated with lower histologic grade, pT, pN, tumor-node-metastasis (TNM) stage, DBC1 (p<0.001), and SIRT1 (p=0.001). Expression of SIRT1 and DBC1 was not associated with p53 (p=0.063 and p=0.060). DBC1 was an independent good prognostic factor in multivariate analysis (p=0.012). Conclusions: SIRC1 and DBC1 can be considered to be good prognostic factors in gastric adenocarcinoma.

    Original languageEnglish
    Pages (from-to)523-531
    Number of pages9
    JournalKorean Journal of Pathology
    Volume46
    Issue number6
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Adenocarcinoma
    • DBC1 protein
    • Human
    • SIRT1 protein
    • Stomach

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine

    Fingerprint

    Dive into the research topics of 'Expression of SIRT1 and DBC1 in gastric adenocarcinoma'. Together they form a unique fingerprint.

    Cite this