Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner

Byung Cheon Lee, Hae Min Lee, Sorah Kim, Andrei S. Avanesov, Aro Lee, Bok Hwan Chun, Gerd Vorbruggen, Vadim N. Gladyshev

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Accumulation of oxidized amino acids, including methionine, has been implicated in aging. The ability to reduce one of the products of methionine oxidation, free methionine-R-sulfoxide (Met-R-SO), is widespread in microorganisms, but during evolution this function, conferred by the enzyme fRMsr, was lost in metazoa. We examined whether restoration of the fRMsr function in an animal can alleviate the consequences of methionine oxidation. Ectopic expression of yeast fRMsr supported the ability of Drosophila to catalyze free Met-R-SO reduction without affecting fecundity, food consumption, and response to starvation. fRMsr expression also increased resistance to oxidative stress. Moreover, it extended lifespan of flies in a methionine-dependent manner. Thus, expression of an oxidoreductase lost during evolution can enhance metabolic and redox functions and lead to an increase in lifespan in an animal model. More broadly, our study exposes the potential of a combination of genetic and nutritional strategies in lifespan control.

Original languageEnglish
Article number15090
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

Fingerprint

Methionine
Drosophila
Nutrigenomics
Starvation
Diptera
Oxidation-Reduction
Fertility
Oxidoreductases
Oxidative Stress
Animal Models
Yeasts
methionine sulfoxide reductase
Amino Acids
Food
Enzymes
methionine sulfoxide

ASJC Scopus subject areas

  • General

Cite this

Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner. / Lee, Byung Cheon; Lee, Hae Min; Kim, Sorah; Avanesov, Andrei S.; Lee, Aro; Chun, Bok Hwan; Vorbruggen, Gerd; Gladyshev, Vadim N.

In: Scientific Reports, Vol. 8, No. 1, 15090, 01.12.2018.

Research output: Contribution to journalArticle

Lee, Byung Cheon ; Lee, Hae Min ; Kim, Sorah ; Avanesov, Andrei S. ; Lee, Aro ; Chun, Bok Hwan ; Vorbruggen, Gerd ; Gladyshev, Vadim N. / Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
@article{f4851e0bf337422ea05f51c139b919b1,
title = "Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner",
abstract = "Accumulation of oxidized amino acids, including methionine, has been implicated in aging. The ability to reduce one of the products of methionine oxidation, free methionine-R-sulfoxide (Met-R-SO), is widespread in microorganisms, but during evolution this function, conferred by the enzyme fRMsr, was lost in metazoa. We examined whether restoration of the fRMsr function in an animal can alleviate the consequences of methionine oxidation. Ectopic expression of yeast fRMsr supported the ability of Drosophila to catalyze free Met-R-SO reduction without affecting fecundity, food consumption, and response to starvation. fRMsr expression also increased resistance to oxidative stress. Moreover, it extended lifespan of flies in a methionine-dependent manner. Thus, expression of an oxidoreductase lost during evolution can enhance metabolic and redox functions and lead to an increase in lifespan in an animal model. More broadly, our study exposes the potential of a combination of genetic and nutritional strategies in lifespan control.",
author = "Lee, {Byung Cheon} and Lee, {Hae Min} and Sorah Kim and Avanesov, {Andrei S.} and Aro Lee and Chun, {Bok Hwan} and Gerd Vorbruggen and Gladyshev, {Vadim N.}",
year = "2018",
month = "12",
day = "1",
doi = "10.1038/s41598-017-15090-5",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner

AU - Lee, Byung Cheon

AU - Lee, Hae Min

AU - Kim, Sorah

AU - Avanesov, Andrei S.

AU - Lee, Aro

AU - Chun, Bok Hwan

AU - Vorbruggen, Gerd

AU - Gladyshev, Vadim N.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Accumulation of oxidized amino acids, including methionine, has been implicated in aging. The ability to reduce one of the products of methionine oxidation, free methionine-R-sulfoxide (Met-R-SO), is widespread in microorganisms, but during evolution this function, conferred by the enzyme fRMsr, was lost in metazoa. We examined whether restoration of the fRMsr function in an animal can alleviate the consequences of methionine oxidation. Ectopic expression of yeast fRMsr supported the ability of Drosophila to catalyze free Met-R-SO reduction without affecting fecundity, food consumption, and response to starvation. fRMsr expression also increased resistance to oxidative stress. Moreover, it extended lifespan of flies in a methionine-dependent manner. Thus, expression of an oxidoreductase lost during evolution can enhance metabolic and redox functions and lead to an increase in lifespan in an animal model. More broadly, our study exposes the potential of a combination of genetic and nutritional strategies in lifespan control.

AB - Accumulation of oxidized amino acids, including methionine, has been implicated in aging. The ability to reduce one of the products of methionine oxidation, free methionine-R-sulfoxide (Met-R-SO), is widespread in microorganisms, but during evolution this function, conferred by the enzyme fRMsr, was lost in metazoa. We examined whether restoration of the fRMsr function in an animal can alleviate the consequences of methionine oxidation. Ectopic expression of yeast fRMsr supported the ability of Drosophila to catalyze free Met-R-SO reduction without affecting fecundity, food consumption, and response to starvation. fRMsr expression also increased resistance to oxidative stress. Moreover, it extended lifespan of flies in a methionine-dependent manner. Thus, expression of an oxidoreductase lost during evolution can enhance metabolic and redox functions and lead to an increase in lifespan in an animal model. More broadly, our study exposes the potential of a combination of genetic and nutritional strategies in lifespan control.

UR - http://www.scopus.com/inward/record.url?scp=85041593911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041593911&partnerID=8YFLogxK

U2 - 10.1038/s41598-017-15090-5

DO - 10.1038/s41598-017-15090-5

M3 - Article

C2 - 29343716

AN - SCOPUS:85041593911

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 15090

ER -