Expression pattern and functional role of Phc2 during activation of helper T cells after antigenic stimulation

Kyu Won Cho, Joonbeom Bae, Suk Jun Lee, Taehoon Chun

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Polycomb group (PcG) proteins, which are conserved from invertebrates to mammals, are associated with epigenetic regulation of many cell fates. The activities of PcG proteins are largely associated with modulation of specific immune reactions. However, no study has attempted to explore the role of Phc2, a subunit of polycomb repressive complex 1, on helper T (Th) cell activation. Presently, Phc2 expression was down-regulated in activated Th cells. The ectopic expression of Phc2 in Th cells inhibited Th cell proliferation and secretion of interleukin-2 from Th cells upon antigen-specific activation. Phc2 may act as a negative regulator that inhibits the activity of Th cells.

Original languageEnglish
Pages (from-to)360-370
Number of pages11
JournalIn Vitro Cellular and Developmental Biology - Animal
Volume49
Issue number5
DOIs
Publication statusPublished - 2013 May

Keywords

  • Cell proliferation
  • Helper T cell
  • IL-2
  • Phc2
  • Polycomb repressive complex 1

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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