Expression Patterns of Glucose Transporter-1 Gene and Thyroid Specific Genes in Human Papillary Thyroid Carcinoma

Sungeun Kim, June Key Chung, Hae Sook Min, Joo Hyun Kang, Do Joon Park, Jae Min Jeong, Dong Soo Lee, Sung Hwae Park, Bo Youn Cho, Sinae Lee, Myung Chul Lee

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose: The expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the expressions of these genes were compared with cancer differentiation grades. Materials and Methods: Twenty-four human papillary carcinoma tissues were included in this study. The expressions of Glut-1- and thyroid-specific genes [sodium/iodide symporter (NIS), thyroid peroxidase, thyroglobulin, TSH receptor and pendrin] were analyzed by RT-PCR. Expression levels were expressed as ratios versus the expression of beta-actin. Pathologic differentiation of papillary carcinoma was classified into a relatively well-differentiated group (n = 13) and relatively less differentiated group (n = 11). Results: Glut-1 gene expression was significantly higher in the less differentiated group (0.66 ± 0.04) than in the well-differentiated group (0.59 ± 0.07). The expression levels of the NIS, PD and TG genes were significantly higher in the well-differentiated group (NIS: 0.67 ± 0.20, PD: 0.65 ± 0.21, TG: 0.74 ± 0.16) than in the less differentiated group (NIS: 0.36 ± 0.05, PD: 0.49 ± 0.08, TG: 0.60 ± 0.11), respectively. A significant negative correlation was found between Glut-1 and NIS expression, and positive correlations were found between NIS and TG, and between NIS and PD. Conclusion: The NIS, PD and TG genes were highly expressed in well-differentiated thyroid carcinomas, whereas the Glut-1 gene was highly expressed in less differentiated thyroid carcinomas. These findings provide a molecular rationale for the management of papillary carcinoma, especially in the selection of FDG PET or radioiodine whole-body scan and I-131-based therapy.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalNuclear Medicine and Molecular Imaging
Volume48
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

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Facilitative Glucose Transport Proteins
Thyroid Gland
Papillary Carcinoma
Genes
Thyroid Neoplasms
Gene Expression
Whole Body Imaging
Thyrotropin Receptors
Iodide Peroxidase
Papillary Thyroid cancer
Actins
Polymerase Chain Reaction
Neoplasms

Keywords

  • Glucose transporter-1
  • Papillary thyroid cancer
  • Pendrin
  • Sodium/iodide symporter
  • Thyroglobulin
  • Thyroid peroxidase
  • TSH receptor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Expression Patterns of Glucose Transporter-1 Gene and Thyroid Specific Genes in Human Papillary Thyroid Carcinoma. / Kim, Sungeun; Chung, June Key; Min, Hae Sook; Kang, Joo Hyun; Park, Do Joon; Jeong, Jae Min; Lee, Dong Soo; Park, Sung Hwae; Cho, Bo Youn; Lee, Sinae; Lee, Myung Chul.

In: Nuclear Medicine and Molecular Imaging, Vol. 48, No. 2, 01.01.2014, p. 91-97.

Research output: Contribution to journalArticle

Kim, S, Chung, JK, Min, HS, Kang, JH, Park, DJ, Jeong, JM, Lee, DS, Park, SH, Cho, BY, Lee, S & Lee, MC 2014, 'Expression Patterns of Glucose Transporter-1 Gene and Thyroid Specific Genes in Human Papillary Thyroid Carcinoma', Nuclear Medicine and Molecular Imaging, vol. 48, no. 2, pp. 91-97. https://doi.org/10.1007/s13139-013-0249-x
Kim, Sungeun ; Chung, June Key ; Min, Hae Sook ; Kang, Joo Hyun ; Park, Do Joon ; Jeong, Jae Min ; Lee, Dong Soo ; Park, Sung Hwae ; Cho, Bo Youn ; Lee, Sinae ; Lee, Myung Chul. / Expression Patterns of Glucose Transporter-1 Gene and Thyroid Specific Genes in Human Papillary Thyroid Carcinoma. In: Nuclear Medicine and Molecular Imaging. 2014 ; Vol. 48, No. 2. pp. 91-97.
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AU - Kim, Sungeun

AU - Chung, June Key

AU - Min, Hae Sook

AU - Kang, Joo Hyun

AU - Park, Do Joon

AU - Jeong, Jae Min

AU - Lee, Dong Soo

AU - Park, Sung Hwae

AU - Cho, Bo Youn

AU - Lee, Sinae

AU - Lee, Myung Chul

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N2 - Purpose: The expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the expressions of these genes were compared with cancer differentiation grades. Materials and Methods: Twenty-four human papillary carcinoma tissues were included in this study. The expressions of Glut-1- and thyroid-specific genes [sodium/iodide symporter (NIS), thyroid peroxidase, thyroglobulin, TSH receptor and pendrin] were analyzed by RT-PCR. Expression levels were expressed as ratios versus the expression of beta-actin. Pathologic differentiation of papillary carcinoma was classified into a relatively well-differentiated group (n = 13) and relatively less differentiated group (n = 11). Results: Glut-1 gene expression was significantly higher in the less differentiated group (0.66 ± 0.04) than in the well-differentiated group (0.59 ± 0.07). The expression levels of the NIS, PD and TG genes were significantly higher in the well-differentiated group (NIS: 0.67 ± 0.20, PD: 0.65 ± 0.21, TG: 0.74 ± 0.16) than in the less differentiated group (NIS: 0.36 ± 0.05, PD: 0.49 ± 0.08, TG: 0.60 ± 0.11), respectively. A significant negative correlation was found between Glut-1 and NIS expression, and positive correlations were found between NIS and TG, and between NIS and PD. Conclusion: The NIS, PD and TG genes were highly expressed in well-differentiated thyroid carcinomas, whereas the Glut-1 gene was highly expressed in less differentiated thyroid carcinomas. These findings provide a molecular rationale for the management of papillary carcinoma, especially in the selection of FDG PET or radioiodine whole-body scan and I-131-based therapy.

AB - Purpose: The expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the expressions of these genes were compared with cancer differentiation grades. Materials and Methods: Twenty-four human papillary carcinoma tissues were included in this study. The expressions of Glut-1- and thyroid-specific genes [sodium/iodide symporter (NIS), thyroid peroxidase, thyroglobulin, TSH receptor and pendrin] were analyzed by RT-PCR. Expression levels were expressed as ratios versus the expression of beta-actin. Pathologic differentiation of papillary carcinoma was classified into a relatively well-differentiated group (n = 13) and relatively less differentiated group (n = 11). Results: Glut-1 gene expression was significantly higher in the less differentiated group (0.66 ± 0.04) than in the well-differentiated group (0.59 ± 0.07). The expression levels of the NIS, PD and TG genes were significantly higher in the well-differentiated group (NIS: 0.67 ± 0.20, PD: 0.65 ± 0.21, TG: 0.74 ± 0.16) than in the less differentiated group (NIS: 0.36 ± 0.05, PD: 0.49 ± 0.08, TG: 0.60 ± 0.11), respectively. A significant negative correlation was found between Glut-1 and NIS expression, and positive correlations were found between NIS and TG, and between NIS and PD. Conclusion: The NIS, PD and TG genes were highly expressed in well-differentiated thyroid carcinomas, whereas the Glut-1 gene was highly expressed in less differentiated thyroid carcinomas. These findings provide a molecular rationale for the management of papillary carcinoma, especially in the selection of FDG PET or radioiodine whole-body scan and I-131-based therapy.

KW - Glucose transporter-1

KW - Papillary thyroid cancer

KW - Pendrin

KW - Sodium/iodide symporter

KW - Thyroglobulin

KW - Thyroid peroxidase

KW - TSH receptor

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