Extents of white matter lesions and increased intraventricular extension of intracerebral hemorrhage

Beom Joon Kim, Seung Hoon Lee, Wi Sun Ryu, Chi Kyung Kim, Jong Won Chung, Dohoung Kim, Hong Kyun Park, Byung Woo Yoon

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

OBJECTIVES: To determine whether the extent of white matter lesions on a CT scan of acute intracerebral hemorrhage patients is associated with the prevalence and severity of intraventricular extension of hemorrhage. DESIGN AND SETTING: A post hoc analysis of Acute Brain Bleeding Analysis-IntraCerebral Hemorrhage cohort, a nationwide prospective cohort of acute intracerebral hemorrhage patients (total number of cohort subjects, 1,604). PATIENTS: Spontaneous intracerebral hemorrhage patients (n = 1,262). INTERVENTIONS: None. MEASUREMENTS: The authors analyzed CT scan images taken within 48 hours after stroke onset. Extent of white matter lesions, volume of intracerebral hemorrhage, presence of intraventricular extension of hemorrhage, and intraventricular extension of hemorrhage score (approximation of intraventricular extension of hemorrhage volume) were measured using CT scans, and demographic, laboratory, clinical, and mortality data were also gathered through review of medical records and retrieval from the governmental statistical archive. MAIN RESULTS: The frequency of intraventricular extension of hemorrhage in our population was 27.2% (343 subjects). The proportion of extensive white matter lesions in intraventricular extension of hemorrhage subjects (33.8%) was higher than that of non-intraventricular extension of hemorrhage cases (16.3%; p < 0.01). Multivariable analysis showed that mild (odds ratio, 1.48; 95% confidence interval 1.05-0.09; p < 0.01) and extensive (odds ratio, 2.73; 95% confidence interval 1.88-3.98; p < 0.01) white matter lesions were significantly associated with the presence of intraventricular extension of hemorrhage in spontaneous intracerebral hemorrhage patients. The estimated mean of the intraventricular extension of hemorrhage score from the extensive white matter lesions group (9.09 ± 0.76) was significantly higher than that of the no white matter lesions group (6.72 ± 0.78; p < 0.01 from analyses of covariances) after adjustment for relevant covariates. CONCLUSIONS: We documented that the severity of white matter lesions is related to the occurrence and amount of intraventricular extension of hemorrhage in spontaneous intracerebral hemorrhage cases.

Original languageEnglish
Pages (from-to)1325-1331
Number of pages7
JournalCritical Care Medicine
Volume41
Issue number5
DOIs
Publication statusPublished - 2013 May 1
Externally publishedYes

Fingerprint

Cerebral Hemorrhage
Hemorrhage
White Matter
Odds Ratio
Confidence Intervals
Medical Records
Stroke
Demography

Keywords

  • clinical outcome
  • hemorrhagic stroke
  • intracerebral hemorrhage
  • intraventricular hemorrhage
  • white matter hyperintensity
  • white matter lesion

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Extents of white matter lesions and increased intraventricular extension of intracerebral hemorrhage. / Kim, Beom Joon; Lee, Seung Hoon; Ryu, Wi Sun; Kim, Chi Kyung; Chung, Jong Won; Kim, Dohoung; Park, Hong Kyun; Yoon, Byung Woo.

In: Critical Care Medicine, Vol. 41, No. 5, 01.05.2013, p. 1325-1331.

Research output: Contribution to journalArticle

Kim, Beom Joon ; Lee, Seung Hoon ; Ryu, Wi Sun ; Kim, Chi Kyung ; Chung, Jong Won ; Kim, Dohoung ; Park, Hong Kyun ; Yoon, Byung Woo. / Extents of white matter lesions and increased intraventricular extension of intracerebral hemorrhage. In: Critical Care Medicine. 2013 ; Vol. 41, No. 5. pp. 1325-1331.
@article{d25c2cf09ef14d59bcc9ab13ada5d303,
title = "Extents of white matter lesions and increased intraventricular extension of intracerebral hemorrhage",
abstract = "OBJECTIVES: To determine whether the extent of white matter lesions on a CT scan of acute intracerebral hemorrhage patients is associated with the prevalence and severity of intraventricular extension of hemorrhage. DESIGN AND SETTING: A post hoc analysis of Acute Brain Bleeding Analysis-IntraCerebral Hemorrhage cohort, a nationwide prospective cohort of acute intracerebral hemorrhage patients (total number of cohort subjects, 1,604). PATIENTS: Spontaneous intracerebral hemorrhage patients (n = 1,262). INTERVENTIONS: None. MEASUREMENTS: The authors analyzed CT scan images taken within 48 hours after stroke onset. Extent of white matter lesions, volume of intracerebral hemorrhage, presence of intraventricular extension of hemorrhage, and intraventricular extension of hemorrhage score (approximation of intraventricular extension of hemorrhage volume) were measured using CT scans, and demographic, laboratory, clinical, and mortality data were also gathered through review of medical records and retrieval from the governmental statistical archive. MAIN RESULTS: The frequency of intraventricular extension of hemorrhage in our population was 27.2{\%} (343 subjects). The proportion of extensive white matter lesions in intraventricular extension of hemorrhage subjects (33.8{\%}) was higher than that of non-intraventricular extension of hemorrhage cases (16.3{\%}; p < 0.01). Multivariable analysis showed that mild (odds ratio, 1.48; 95{\%} confidence interval 1.05-0.09; p < 0.01) and extensive (odds ratio, 2.73; 95{\%} confidence interval 1.88-3.98; p < 0.01) white matter lesions were significantly associated with the presence of intraventricular extension of hemorrhage in spontaneous intracerebral hemorrhage patients. The estimated mean of the intraventricular extension of hemorrhage score from the extensive white matter lesions group (9.09 ± 0.76) was significantly higher than that of the no white matter lesions group (6.72 ± 0.78; p < 0.01 from analyses of covariances) after adjustment for relevant covariates. CONCLUSIONS: We documented that the severity of white matter lesions is related to the occurrence and amount of intraventricular extension of hemorrhage in spontaneous intracerebral hemorrhage cases.",
keywords = "clinical outcome, hemorrhagic stroke, intracerebral hemorrhage, intraventricular hemorrhage, white matter hyperintensity, white matter lesion",
author = "Kim, {Beom Joon} and Lee, {Seung Hoon} and Ryu, {Wi Sun} and Kim, {Chi Kyung} and Chung, {Jong Won} and Dohoung Kim and Park, {Hong Kyun} and Yoon, {Byung Woo}",
year = "2013",
month = "5",
day = "1",
doi = "10.1097/CCM.0b013e31827c05e9",
language = "English",
volume = "41",
pages = "1325--1331",
journal = "Critical Care Medicine",
issn = "0090-3493",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Extents of white matter lesions and increased intraventricular extension of intracerebral hemorrhage

AU - Kim, Beom Joon

AU - Lee, Seung Hoon

AU - Ryu, Wi Sun

AU - Kim, Chi Kyung

AU - Chung, Jong Won

AU - Kim, Dohoung

AU - Park, Hong Kyun

AU - Yoon, Byung Woo

PY - 2013/5/1

Y1 - 2013/5/1

N2 - OBJECTIVES: To determine whether the extent of white matter lesions on a CT scan of acute intracerebral hemorrhage patients is associated with the prevalence and severity of intraventricular extension of hemorrhage. DESIGN AND SETTING: A post hoc analysis of Acute Brain Bleeding Analysis-IntraCerebral Hemorrhage cohort, a nationwide prospective cohort of acute intracerebral hemorrhage patients (total number of cohort subjects, 1,604). PATIENTS: Spontaneous intracerebral hemorrhage patients (n = 1,262). INTERVENTIONS: None. MEASUREMENTS: The authors analyzed CT scan images taken within 48 hours after stroke onset. Extent of white matter lesions, volume of intracerebral hemorrhage, presence of intraventricular extension of hemorrhage, and intraventricular extension of hemorrhage score (approximation of intraventricular extension of hemorrhage volume) were measured using CT scans, and demographic, laboratory, clinical, and mortality data were also gathered through review of medical records and retrieval from the governmental statistical archive. MAIN RESULTS: The frequency of intraventricular extension of hemorrhage in our population was 27.2% (343 subjects). The proportion of extensive white matter lesions in intraventricular extension of hemorrhage subjects (33.8%) was higher than that of non-intraventricular extension of hemorrhage cases (16.3%; p < 0.01). Multivariable analysis showed that mild (odds ratio, 1.48; 95% confidence interval 1.05-0.09; p < 0.01) and extensive (odds ratio, 2.73; 95% confidence interval 1.88-3.98; p < 0.01) white matter lesions were significantly associated with the presence of intraventricular extension of hemorrhage in spontaneous intracerebral hemorrhage patients. The estimated mean of the intraventricular extension of hemorrhage score from the extensive white matter lesions group (9.09 ± 0.76) was significantly higher than that of the no white matter lesions group (6.72 ± 0.78; p < 0.01 from analyses of covariances) after adjustment for relevant covariates. CONCLUSIONS: We documented that the severity of white matter lesions is related to the occurrence and amount of intraventricular extension of hemorrhage in spontaneous intracerebral hemorrhage cases.

AB - OBJECTIVES: To determine whether the extent of white matter lesions on a CT scan of acute intracerebral hemorrhage patients is associated with the prevalence and severity of intraventricular extension of hemorrhage. DESIGN AND SETTING: A post hoc analysis of Acute Brain Bleeding Analysis-IntraCerebral Hemorrhage cohort, a nationwide prospective cohort of acute intracerebral hemorrhage patients (total number of cohort subjects, 1,604). PATIENTS: Spontaneous intracerebral hemorrhage patients (n = 1,262). INTERVENTIONS: None. MEASUREMENTS: The authors analyzed CT scan images taken within 48 hours after stroke onset. Extent of white matter lesions, volume of intracerebral hemorrhage, presence of intraventricular extension of hemorrhage, and intraventricular extension of hemorrhage score (approximation of intraventricular extension of hemorrhage volume) were measured using CT scans, and demographic, laboratory, clinical, and mortality data were also gathered through review of medical records and retrieval from the governmental statistical archive. MAIN RESULTS: The frequency of intraventricular extension of hemorrhage in our population was 27.2% (343 subjects). The proportion of extensive white matter lesions in intraventricular extension of hemorrhage subjects (33.8%) was higher than that of non-intraventricular extension of hemorrhage cases (16.3%; p < 0.01). Multivariable analysis showed that mild (odds ratio, 1.48; 95% confidence interval 1.05-0.09; p < 0.01) and extensive (odds ratio, 2.73; 95% confidence interval 1.88-3.98; p < 0.01) white matter lesions were significantly associated with the presence of intraventricular extension of hemorrhage in spontaneous intracerebral hemorrhage patients. The estimated mean of the intraventricular extension of hemorrhage score from the extensive white matter lesions group (9.09 ± 0.76) was significantly higher than that of the no white matter lesions group (6.72 ± 0.78; p < 0.01 from analyses of covariances) after adjustment for relevant covariates. CONCLUSIONS: We documented that the severity of white matter lesions is related to the occurrence and amount of intraventricular extension of hemorrhage in spontaneous intracerebral hemorrhage cases.

KW - clinical outcome

KW - hemorrhagic stroke

KW - intracerebral hemorrhage

KW - intraventricular hemorrhage

KW - white matter hyperintensity

KW - white matter lesion

UR - http://www.scopus.com/inward/record.url?scp=84876675504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876675504&partnerID=8YFLogxK

U2 - 10.1097/CCM.0b013e31827c05e9

DO - 10.1097/CCM.0b013e31827c05e9

M3 - Article

C2 - 23388516

AN - SCOPUS:84876675504

VL - 41

SP - 1325

EP - 1331

JO - Critical Care Medicine

JF - Critical Care Medicine

SN - 0090-3493

IS - 5

ER -