Extracorporeal Magnetic Innervation Therapy in Children with Refractory Monosymptomatic Nocturnal Enuresis

Seok Ho Kang, Jae Hyun Bae, Kang Soo Shim, Hong Seok Park, Jun Cheon, Jeong Gu Lee, Duck Ki Yoon, Je-Jong Kim, Du Geon Moon

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Abstract

Objectives: To evaluate the effect of extracorporeal magnetic innervation (ExMI) therapy in children with refractory monosymptomatic nocturnal enuresis (MNE). Methods: A total of 55 children (34 boys and 21 girls, median age 8.0 years, range 5 to 13) who wetted the bed more than twice per week because of MNE that was refractory to treatment with desmopressin, anticholinergics, and enuretic alarm were assessed prospectively using a voiding diary before and after ExMI, administered once a week for at least 4 weeks with a size-adjusted magnetic chair (each session lasted 20 minutes). Results: After all sessions of ExMI, the mean frequency of nocturnal enuresis decreased significantly to 2.09 ± 2.47 in all patients (P = 0.04), and the mean functional bladder capacity increased 1.88 times in all patients (P = 0.00). In total, 63.6% of our patients had a nocturnal enuresis frequency of less than 50% after a mean of 6.62 ± 4.26 ExMI sessions. Conclusions: From our results, reduced functional bladder capacity might be the main pathophysiologic cause in children with MNE refractory to established treatment. ExMI might have an acute inhibitory effect in these children with refractory MNE by increasing functional bladder capacity. However, long-term follow-up data and controlled study with a sham-stimulation group are necessary to determine the durability of this new therapy for refractory MNE.

Original languageEnglish
Pages (from-to)576-580
Number of pages5
JournalUrology
Volume70
Issue number3
DOIs
Publication statusPublished - 2007 Sep 1

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Nocturnal Enuresis
Urinary Bladder
Therapeutics
Deamino Arginine Vasopressin
Cholinergic Antagonists

ASJC Scopus subject areas

  • Urology

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Extracorporeal Magnetic Innervation Therapy in Children with Refractory Monosymptomatic Nocturnal Enuresis. / Kang, Seok Ho; Bae, Jae Hyun; Shim, Kang Soo; Park, Hong Seok; Cheon, Jun; Lee, Jeong Gu; Yoon, Duck Ki; Kim, Je-Jong; Moon, Du Geon.

In: Urology, Vol. 70, No. 3, 01.09.2007, p. 576-580.

Research output: Contribution to journalArticle

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AU - Bae, Jae Hyun

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AU - Park, Hong Seok

AU - Cheon, Jun

AU - Lee, Jeong Gu

AU - Yoon, Duck Ki

AU - Kim, Je-Jong

AU - Moon, Du Geon

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N2 - Objectives: To evaluate the effect of extracorporeal magnetic innervation (ExMI) therapy in children with refractory monosymptomatic nocturnal enuresis (MNE). Methods: A total of 55 children (34 boys and 21 girls, median age 8.0 years, range 5 to 13) who wetted the bed more than twice per week because of MNE that was refractory to treatment with desmopressin, anticholinergics, and enuretic alarm were assessed prospectively using a voiding diary before and after ExMI, administered once a week for at least 4 weeks with a size-adjusted magnetic chair (each session lasted 20 minutes). Results: After all sessions of ExMI, the mean frequency of nocturnal enuresis decreased significantly to 2.09 ± 2.47 in all patients (P = 0.04), and the mean functional bladder capacity increased 1.88 times in all patients (P = 0.00). In total, 63.6% of our patients had a nocturnal enuresis frequency of less than 50% after a mean of 6.62 ± 4.26 ExMI sessions. Conclusions: From our results, reduced functional bladder capacity might be the main pathophysiologic cause in children with MNE refractory to established treatment. ExMI might have an acute inhibitory effect in these children with refractory MNE by increasing functional bladder capacity. However, long-term follow-up data and controlled study with a sham-stimulation group are necessary to determine the durability of this new therapy for refractory MNE.

AB - Objectives: To evaluate the effect of extracorporeal magnetic innervation (ExMI) therapy in children with refractory monosymptomatic nocturnal enuresis (MNE). Methods: A total of 55 children (34 boys and 21 girls, median age 8.0 years, range 5 to 13) who wetted the bed more than twice per week because of MNE that was refractory to treatment with desmopressin, anticholinergics, and enuretic alarm were assessed prospectively using a voiding diary before and after ExMI, administered once a week for at least 4 weeks with a size-adjusted magnetic chair (each session lasted 20 minutes). Results: After all sessions of ExMI, the mean frequency of nocturnal enuresis decreased significantly to 2.09 ± 2.47 in all patients (P = 0.04), and the mean functional bladder capacity increased 1.88 times in all patients (P = 0.00). In total, 63.6% of our patients had a nocturnal enuresis frequency of less than 50% after a mean of 6.62 ± 4.26 ExMI sessions. Conclusions: From our results, reduced functional bladder capacity might be the main pathophysiologic cause in children with MNE refractory to established treatment. ExMI might have an acute inhibitory effect in these children with refractory MNE by increasing functional bladder capacity. However, long-term follow-up data and controlled study with a sham-stimulation group are necessary to determine the durability of this new therapy for refractory MNE.

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