Abstract
Purpose: The purpose was to describe the magnetic resonance (MR) findings of extracranial skeletal Langerhans cell histiocytosis according to the radiologic evolutional phases. Materials and methods: Twenty-two patients with pathologically confirmed extracranial skeletal Langerhans cell histiocytosis were included. The lesions were classified as early, mid, and late phases according to the radiologic evolutional phases. MR images were retrospectively analyzed regarding signal intensity, internal hypointense band, fluid levels, periosteal reaction, adjacent bone marrow and soft tissue abnormal signal, and patterns of contrast enhancement in each phase. Results: According to the radiologic evolutional phases, there were 4 patients with early phase, 16 with mid phase, and 2 with late phase. All cases showed hypointense to intermediate signal intensity on T1-weighted images. On T2-weighted images, 12 (55%) of the 22 lesions were hyperintense, and 10 (45%) showed intermediate signal. All lesions showed diffusely heterogeneous signal on T2-weighted images. Internal low-signal bands of the lesions were observed in 13 cases (59%). There were two cases with fluid levels in mid phase. Periosteal reaction was observed in 13 (59%) cases. Adjacent bone marrow or soft tissue abnormal signal was observed in 20 cases (91%), respectively. According to early, mid, and late phases, bone marrow and soft tissue abnormal signals were observed in 100%, 100%, and 0% cases, respectively. Soft tissue mass was seen in eight cases (36%). Ten (46%) lesions showed cortical destruction, including one patient with a pathologic fracture. Among 21 patients with contrast infusion, diffuse enhancement was observed in 19 patients (90%), and marginal and septal enhancement was seen in 2 patients (10%). Conclusion: MR imaging was helpful in the diagnosis of extracranial skeletal Langerhans cell histiocytosis, particularly in early and mid phases.
| Original language | English |
|---|---|
| Pages (from-to) | 466-471 |
| Number of pages | 6 |
| Journal | Clinical Imaging |
| Volume | 36 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2012 Sep 1 |
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Keywords
- Bone
- Eosinophilic granuloma
- Extracranial Langerhans cell histiocytosis
- MR imaging
- Neoplasms
- Tumors
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Extracranial skeletal Langerhans cell histiocytosis : MR imaging features according to the radiologic evolutional phases. / Jeh, Su Kyung; Jee, Won Hee; Hong, Suk-Joo; Kim, Jee Young; Sung, Mi Sook; Ryu, Kyung Nam; Im, Soo A.; Chun, Kyung Ah; Lee, Yeon Soo; Cho, Jae Hyun.
In: Clinical Imaging, Vol. 36, No. 5, 01.09.2012, p. 466-471.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Extracranial skeletal Langerhans cell histiocytosis
T2 - MR imaging features according to the radiologic evolutional phases
AU - Jeh, Su Kyung
AU - Jee, Won Hee
AU - Hong, Suk-Joo
AU - Kim, Jee Young
AU - Sung, Mi Sook
AU - Ryu, Kyung Nam
AU - Im, Soo A.
AU - Chun, Kyung Ah
AU - Lee, Yeon Soo
AU - Cho, Jae Hyun
PY - 2012/9/1
Y1 - 2012/9/1
N2 - Purpose: The purpose was to describe the magnetic resonance (MR) findings of extracranial skeletal Langerhans cell histiocytosis according to the radiologic evolutional phases. Materials and methods: Twenty-two patients with pathologically confirmed extracranial skeletal Langerhans cell histiocytosis were included. The lesions were classified as early, mid, and late phases according to the radiologic evolutional phases. MR images were retrospectively analyzed regarding signal intensity, internal hypointense band, fluid levels, periosteal reaction, adjacent bone marrow and soft tissue abnormal signal, and patterns of contrast enhancement in each phase. Results: According to the radiologic evolutional phases, there were 4 patients with early phase, 16 with mid phase, and 2 with late phase. All cases showed hypointense to intermediate signal intensity on T1-weighted images. On T2-weighted images, 12 (55%) of the 22 lesions were hyperintense, and 10 (45%) showed intermediate signal. All lesions showed diffusely heterogeneous signal on T2-weighted images. Internal low-signal bands of the lesions were observed in 13 cases (59%). There were two cases with fluid levels in mid phase. Periosteal reaction was observed in 13 (59%) cases. Adjacent bone marrow or soft tissue abnormal signal was observed in 20 cases (91%), respectively. According to early, mid, and late phases, bone marrow and soft tissue abnormal signals were observed in 100%, 100%, and 0% cases, respectively. Soft tissue mass was seen in eight cases (36%). Ten (46%) lesions showed cortical destruction, including one patient with a pathologic fracture. Among 21 patients with contrast infusion, diffuse enhancement was observed in 19 patients (90%), and marginal and septal enhancement was seen in 2 patients (10%). Conclusion: MR imaging was helpful in the diagnosis of extracranial skeletal Langerhans cell histiocytosis, particularly in early and mid phases.
AB - Purpose: The purpose was to describe the magnetic resonance (MR) findings of extracranial skeletal Langerhans cell histiocytosis according to the radiologic evolutional phases. Materials and methods: Twenty-two patients with pathologically confirmed extracranial skeletal Langerhans cell histiocytosis were included. The lesions were classified as early, mid, and late phases according to the radiologic evolutional phases. MR images were retrospectively analyzed regarding signal intensity, internal hypointense band, fluid levels, periosteal reaction, adjacent bone marrow and soft tissue abnormal signal, and patterns of contrast enhancement in each phase. Results: According to the radiologic evolutional phases, there were 4 patients with early phase, 16 with mid phase, and 2 with late phase. All cases showed hypointense to intermediate signal intensity on T1-weighted images. On T2-weighted images, 12 (55%) of the 22 lesions were hyperintense, and 10 (45%) showed intermediate signal. All lesions showed diffusely heterogeneous signal on T2-weighted images. Internal low-signal bands of the lesions were observed in 13 cases (59%). There were two cases with fluid levels in mid phase. Periosteal reaction was observed in 13 (59%) cases. Adjacent bone marrow or soft tissue abnormal signal was observed in 20 cases (91%), respectively. According to early, mid, and late phases, bone marrow and soft tissue abnormal signals were observed in 100%, 100%, and 0% cases, respectively. Soft tissue mass was seen in eight cases (36%). Ten (46%) lesions showed cortical destruction, including one patient with a pathologic fracture. Among 21 patients with contrast infusion, diffuse enhancement was observed in 19 patients (90%), and marginal and septal enhancement was seen in 2 patients (10%). Conclusion: MR imaging was helpful in the diagnosis of extracranial skeletal Langerhans cell histiocytosis, particularly in early and mid phases.
KW - Bone
KW - Eosinophilic granuloma
KW - Extracranial Langerhans cell histiocytosis
KW - MR imaging
KW - Neoplasms
KW - Tumors
UR - http://www.scopus.com/inward/record.url?scp=84865401629&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865401629&partnerID=8YFLogxK
U2 - 10.1016/j.clinimag.2012.01.002
DO - 10.1016/j.clinimag.2012.01.002
M3 - Article
VL - 36
SP - 466
EP - 471
JO - Clinical Imaging
JF - Clinical Imaging
SN - 0899-7071
IS - 5
ER -