Extract of Rhus verniciflua stokes protects the diet-induced hyperlipidemia in mice

Se Jin Jeong, Jong Gil Park, Sinai Kim, Hyae Yon Kweon, Seungwoon Seo, Dae Seung Na, Dongho Lee, Cheol Yi Hong, Chun Soo Na, Mi Sook Dong, Goo Taeg Oh

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6 Citations (Scopus)

Abstract

Rhus verniciflua stokes (RVS) is a popular medicinal plant in oriental medicines which is commonly used to resolve extravasated blood. To elucidate the molecular mechanism of the role of RVS extracts on the regulation of lipid and cholesterol biosynthesis, we investigated whether RVS extract protect the hyperlipidemia in western diet-induced C57BL6/J mice. Mice fed a western diet and additionally RVS extracts was administered orally at a dose of 0.1 or 1 g/kg/day for 2 weeks respectively. Group with higher dose of RVS extract showed a significantly decreased body weight compared with western diet fed mice groups. And total cholesterol, LDL-cholesterol levels and fatty liver formation were also improved especially in group of mice fed western diet supplemented high dose RVS extracts. Next, synthesis of hepatic bile acids were significantly increased in RVS extract fed groups. Furthermore, RVS extracts significantly increase promoter activity of Cyp7a1 via up-regulate the transcriptional expression level of LXRα. Our data suggest that RVS extracts could be a potent therapeutic ingredient for prevent a hyperlipidemia via increase of bile acids biosynthesis.

Original languageEnglish
Pages (from-to)2049-2058
Number of pages10
JournalArchives of Pharmacal Research
Volume38
Issue number11
DOIs
Publication statusPublished - 2015 Nov 1

Keywords

  • Bile acid biosynthesis
  • Cyp7a1
  • Hyperlipidemia
  • Liver X receptor α (LXRα)
  • Rhus verniciflua stokes (RVS)

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine
  • Organic Chemistry

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  • Cite this

    Jeong, S. J., Park, J. G., Kim, S., Kweon, H. Y., Seo, S., Na, D. S., Lee, D., Hong, C. Y., Na, C. S., Dong, M. S., & Oh, G. T. (2015). Extract of Rhus verniciflua stokes protects the diet-induced hyperlipidemia in mice. Archives of Pharmacal Research, 38(11), 2049-2058. https://doi.org/10.1007/s12272-015-0579-6