Extramedullary B lymphoblastic crisis of CML, presenting as a leptomeningeal tumor - A case report

Hoiseon Jeong, Bong Kyung Shin, Sook Young Bae, Sangho Lee, Youngjune Ryu, Han Kyeom Kim, Insun Kim

Research output: Contribution to journalArticle

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Abstract

We report here on a rare case of a patient who presented with an extramedullary B lymphoblastic crisis as an initial manifestation of chronic myelogenous leukemia (CML). A 71-year-old man visited the emergency room due to suddenly developed dysarthria and right side weakness. Emergency craniotomy was done under the presumptive diagnosis of subdural hemorrhage. During the operation, a poorly demarcated firm mass was identified in the leptomeningeal space. Microscopically, the majority of the tumor was composed of monotonous immature cells with blast morphology, and these cells were immunoreactive for TdT, CD34, CD10 and CD20, indicating the precursor B-cell phenotype. The peripheral area of the tumor consisted of myeloid cells in various stages of maturation, and these cells were reactive for myeloperoxidase, chloroacetate esterase, CD43 and CD15. FISH analysis using the LSI bcr-abl dual color probe showed gene fusion signals in both the B-lymphoblasts and myeloid cells. The peripheral blood and bone marrow findings were consistent with CML with no evidence of a blast crisis. Cytogenetic study of the bone marrow demonstrated the 46, XY, t(9;22)(q34;q11) chromosome. A diagnosis of extramedullary B lymphoblastic blast crisis in a patient with Philadelphia chromosome-positive CML was made. Despite treatment, the patient died 3 months after he was diagnosed.

Original languageEnglish
Pages (from-to)482-488
Number of pages7
JournalKorean Journal of Pathology
Volume43
Issue number5
DOIs
Publication statusPublished - 2009 Oct 1

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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Blast Crisis
Myeloid Cells
Bone Marrow
Philadelphia Chromosome
Dysarthria
Neoplasms
Subdural Hematoma
B-Lymphoid Precursor Cells
Craniotomy
Gene Fusion
Cytogenetics
Peroxidase
Hospital Emergency Service
Emergencies
Color
Chromosomes
Phenotype
Therapeutics

Keywords

  • Blast crisis
  • Chronic myelogenous leukemia
  • Fluorescent in situ hybridization
  • Leptomeninges
  • Philadelphia chromosome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Extramedullary B lymphoblastic crisis of CML, presenting as a leptomeningeal tumor - A case report. / Jeong, Hoiseon; Shin, Bong Kyung; Bae, Sook Young; Lee, Sangho; Ryu, Youngjune; Kim, Han Kyeom; Kim, Insun.

In: Korean Journal of Pathology, Vol. 43, No. 5, 01.10.2009, p. 482-488.

Research output: Contribution to journalArticle

Jeong, Hoiseon ; Shin, Bong Kyung ; Bae, Sook Young ; Lee, Sangho ; Ryu, Youngjune ; Kim, Han Kyeom ; Kim, Insun. / Extramedullary B lymphoblastic crisis of CML, presenting as a leptomeningeal tumor - A case report. In: Korean Journal of Pathology. 2009 ; Vol. 43, No. 5. pp. 482-488.
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