Extranodal involvement of diffuse large B-cell lymphoma in the head and neck

An indicator of good prognosis

Doh Young Lee, Karam Kang, Hwaejoon Jung, Young Min Park, Jae-Gu Cho, Seung-Kuk Baek, Soon Young Kwon, Kwang-Yoon Jung, Jeong-Soo Woo

Research output: Contribution to journalArticle

Abstract

Objective: In this study, we analyzed clinicopathological characteristics and survival outcomes according to extranodal involvement of diffuse large B-cell lymphoma (DLBCL) in the head and neck. Methods: A retrospective analysis was conducted on 110 patients from 2004 to 2014 with CD20-positive DLBCL involving the head and neck area. Patients were categorized into two groups, extranodal and nodal, according to involvement of extranodal sites in the head and neck. Outcome measurements for the groups included clinical response to treatment and recurrence rates. Results: Palatine tonsils were the most frequently involved extranodal site in the head and neck (29.1%). Among clinicopathological parameters, proportion of patients with lactate dehydrogenase over 350 IU/L (p = 0.033), cell of origin (p < 0.001), and treatment outcomes (p = 0.007) were significantly different between the two groups. Among cell origin markers CD10, Bcl6, and MUM1, MUM1 was significantly correlated with extranodal involvement (p = 0.029). Recurrence rates were similar between groups, while disease-specific survival was significantly higher in the extranodal group (p = 0.011). Disease-specific survival of the extranodal group was also higher than the nodal group with extranodal involvement of other body sites (p = 0.010). Among patients with negative expression of CD10 (p = 0.015), Bcl6 (p = 0.018), and MUM1 (p = 0.005), survival was longer in the extranodal than the nodal group. Conclusions: DLBCL patients with extranodal involvement of the head and neck may have longer survival outcomes than patients with solely nodal involvement. Increased survival may be more prominent in patients with negative expression of CD10, Bcl6, and MUM1.

Original languageEnglish
JournalAuris Nasus Larynx
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Fingerprint

Lymphoma, Large B-Cell, Diffuse
Neck
Head
Survival
Recurrence
Palatine Tonsil
L-Lactate Dehydrogenase

Keywords

  • Head and neck neoplasms
  • Lymph nodes
  • Lymphoma
  • Prognosis

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

@article{f5b2f530a66d4c5093b71f56be40acc0,
title = "Extranodal involvement of diffuse large B-cell lymphoma in the head and neck: An indicator of good prognosis",
abstract = "Objective: In this study, we analyzed clinicopathological characteristics and survival outcomes according to extranodal involvement of diffuse large B-cell lymphoma (DLBCL) in the head and neck. Methods: A retrospective analysis was conducted on 110 patients from 2004 to 2014 with CD20-positive DLBCL involving the head and neck area. Patients were categorized into two groups, extranodal and nodal, according to involvement of extranodal sites in the head and neck. Outcome measurements for the groups included clinical response to treatment and recurrence rates. Results: Palatine tonsils were the most frequently involved extranodal site in the head and neck (29.1{\%}). Among clinicopathological parameters, proportion of patients with lactate dehydrogenase over 350 IU/L (p = 0.033), cell of origin (p < 0.001), and treatment outcomes (p = 0.007) were significantly different between the two groups. Among cell origin markers CD10, Bcl6, and MUM1, MUM1 was significantly correlated with extranodal involvement (p = 0.029). Recurrence rates were similar between groups, while disease-specific survival was significantly higher in the extranodal group (p = 0.011). Disease-specific survival of the extranodal group was also higher than the nodal group with extranodal involvement of other body sites (p = 0.010). Among patients with negative expression of CD10 (p = 0.015), Bcl6 (p = 0.018), and MUM1 (p = 0.005), survival was longer in the extranodal than the nodal group. Conclusions: DLBCL patients with extranodal involvement of the head and neck may have longer survival outcomes than patients with solely nodal involvement. Increased survival may be more prominent in patients with negative expression of CD10, Bcl6, and MUM1.",
keywords = "Head and neck neoplasms, Lymph nodes, Lymphoma, Prognosis",
author = "Lee, {Doh Young} and Karam Kang and Hwaejoon Jung and Park, {Young Min} and Jae-Gu Cho and Seung-Kuk Baek and Kwon, {Soon Young} and Kwang-Yoon Jung and Jeong-Soo Woo",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.anl.2018.05.006",
language = "English",
journal = "Auris Nasus Larynx",
issn = "0385-8146",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Extranodal involvement of diffuse large B-cell lymphoma in the head and neck

T2 - An indicator of good prognosis

AU - Lee, Doh Young

AU - Kang, Karam

AU - Jung, Hwaejoon

AU - Park, Young Min

AU - Cho, Jae-Gu

AU - Baek, Seung-Kuk

AU - Kwon, Soon Young

AU - Jung, Kwang-Yoon

AU - Woo, Jeong-Soo

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective: In this study, we analyzed clinicopathological characteristics and survival outcomes according to extranodal involvement of diffuse large B-cell lymphoma (DLBCL) in the head and neck. Methods: A retrospective analysis was conducted on 110 patients from 2004 to 2014 with CD20-positive DLBCL involving the head and neck area. Patients were categorized into two groups, extranodal and nodal, according to involvement of extranodal sites in the head and neck. Outcome measurements for the groups included clinical response to treatment and recurrence rates. Results: Palatine tonsils were the most frequently involved extranodal site in the head and neck (29.1%). Among clinicopathological parameters, proportion of patients with lactate dehydrogenase over 350 IU/L (p = 0.033), cell of origin (p < 0.001), and treatment outcomes (p = 0.007) were significantly different between the two groups. Among cell origin markers CD10, Bcl6, and MUM1, MUM1 was significantly correlated with extranodal involvement (p = 0.029). Recurrence rates were similar between groups, while disease-specific survival was significantly higher in the extranodal group (p = 0.011). Disease-specific survival of the extranodal group was also higher than the nodal group with extranodal involvement of other body sites (p = 0.010). Among patients with negative expression of CD10 (p = 0.015), Bcl6 (p = 0.018), and MUM1 (p = 0.005), survival was longer in the extranodal than the nodal group. Conclusions: DLBCL patients with extranodal involvement of the head and neck may have longer survival outcomes than patients with solely nodal involvement. Increased survival may be more prominent in patients with negative expression of CD10, Bcl6, and MUM1.

AB - Objective: In this study, we analyzed clinicopathological characteristics and survival outcomes according to extranodal involvement of diffuse large B-cell lymphoma (DLBCL) in the head and neck. Methods: A retrospective analysis was conducted on 110 patients from 2004 to 2014 with CD20-positive DLBCL involving the head and neck area. Patients were categorized into two groups, extranodal and nodal, according to involvement of extranodal sites in the head and neck. Outcome measurements for the groups included clinical response to treatment and recurrence rates. Results: Palatine tonsils were the most frequently involved extranodal site in the head and neck (29.1%). Among clinicopathological parameters, proportion of patients with lactate dehydrogenase over 350 IU/L (p = 0.033), cell of origin (p < 0.001), and treatment outcomes (p = 0.007) were significantly different between the two groups. Among cell origin markers CD10, Bcl6, and MUM1, MUM1 was significantly correlated with extranodal involvement (p = 0.029). Recurrence rates were similar between groups, while disease-specific survival was significantly higher in the extranodal group (p = 0.011). Disease-specific survival of the extranodal group was also higher than the nodal group with extranodal involvement of other body sites (p = 0.010). Among patients with negative expression of CD10 (p = 0.015), Bcl6 (p = 0.018), and MUM1 (p = 0.005), survival was longer in the extranodal than the nodal group. Conclusions: DLBCL patients with extranodal involvement of the head and neck may have longer survival outcomes than patients with solely nodal involvement. Increased survival may be more prominent in patients with negative expression of CD10, Bcl6, and MUM1.

KW - Head and neck neoplasms

KW - Lymph nodes

KW - Lymphoma

KW - Prognosis

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U2 - 10.1016/j.anl.2018.05.006

DO - 10.1016/j.anl.2018.05.006

M3 - Article

JO - Auris Nasus Larynx

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