Extremely sensitive and wide-range silver ion detection via assessing the integrated surface potential of a DNA-capped gold nanoparticle

Dongtak Lee, Hyungbeen Lee, Gyudo Lee, Insu Kim, Sang Won Lee, Woong Kim, Sang Woo Lee, Jeong Hoon Lee, Jinsung Park, Dae Sung Yoon

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

With the rapid development of nanotechnology and its associated waste stream, public concern is growing over the potential toxicity exposure to heavy metal ions poses to the human body and the environment. Herein, we report an extremely sensitive Kelvin probe force microscopy (KPFM)-based platform for detecting nanotoxic materials (e.g. Ag + ) accomplished by probing the integrated surface potential differences of a single gold nanoparticle on which an interaction between probe DNA and target DNA occurs. This interaction can amplify the surface potential of the nanoparticle owing to the coordination bond mediated by Ag + (cytosine-Ag + -cytosine base pairs). Interestingly, compared with conventional methods, this platform is capable of extremely sensitive Ag + detection (∼1 fM) in a remarkably wide-range (1 fM to 1 μM). Furthermore, this platform enables Ag + detection in a practical sample (general drinking water), and this KPFM-based technique may have the potential to detect other toxic heavy metal ions and single nucleotide polymorphisms by designing specific DNA sequences.

Original languageEnglish
Article number085501
JournalNanotechnology
Volume30
Issue number8
DOIs
Publication statusPublished - 2019 Feb 22

Fingerprint

Heavy Ions
Atomic Force Microscopy
Cytosine
Surface potential
Heavy Metals
Heavy ions
Silver
Gold
Nanoparticles
Metal ions
Microscopic examination
DNA
Ions
Heavy metals
Nanotechnology
Poisons
DNA sequences
DNA Probes
Polymorphism
Human Body

Keywords

  • DNA-metal interaction
  • gold nanoparticle
  • Kevin probe force microscope
  • silver ion
  • surface potential

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

Extremely sensitive and wide-range silver ion detection via assessing the integrated surface potential of a DNA-capped gold nanoparticle. / Lee, Dongtak; Lee, Hyungbeen; Lee, Gyudo; Kim, Insu; Lee, Sang Won; Kim, Woong; Lee, Sang Woo; Lee, Jeong Hoon; Park, Jinsung; Yoon, Dae Sung.

In: Nanotechnology, Vol. 30, No. 8, 085501, 22.02.2019.

Research output: Contribution to journalArticle

Lee, Dongtak ; Lee, Hyungbeen ; Lee, Gyudo ; Kim, Insu ; Lee, Sang Won ; Kim, Woong ; Lee, Sang Woo ; Lee, Jeong Hoon ; Park, Jinsung ; Yoon, Dae Sung. / Extremely sensitive and wide-range silver ion detection via assessing the integrated surface potential of a DNA-capped gold nanoparticle. In: Nanotechnology. 2019 ; Vol. 30, No. 8.
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