Fabrication and compressive strength of porous hydroxyapatite scaffolds with a functionally graded core/shell structure

Young Mi Soon, Kwan Ha Shin, Young Hag Koh, Jong Hoon Lee, Won Young Choi, Hyoun Ee Kim

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

A novel type of porous hydroxyapatite (HA) scaffolds with a functionally graded core/shell structure was fabricated by freeze casting HA/camphene slurries with various HA contents into fugitive molds containing a graphite template with three-dimensionally interconnected pores for the creation of a highly porous core. All the fabricated samples had functionally graded core/shell structures with 3-D periodic pore networks in a core surrounded by a relatively dense shell. The overall porosity of the sample decreased from 60 to 38. vol% with increasing HA content in the HA/camphene slurry from 20 to 36. vol% due to a decrease in porosity in both the core and shell regions. In addition, the compressive strength was improved remarkably from 12 ± 1.1 to 32 ± 3.0 MPa. The in vitro cell test using a pre-osteoblast cell line showed that the samples had good biocompatibility.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalJournal of the European Ceramic Society
Volume31
Issue number1-2
DOIs
Publication statusPublished - 2011 Jan 1

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Keywords

  • Apatite
  • Biomedical applications
  • Mechanical properties
  • Porosity
  • Suspensions

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

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