Fabrication and compressive strength of porous hydroxyapatite scaffolds with a functionally graded core/shell structure

Young Mi Soon; Kwan Ha Shin; Young Hag Koh; Jong Hoon Lee; Won Young Choi; Hyoun Ee Kim

doi:10.1016/j.jeurceramsoc.2010.09.008

Fabrication and compressive strength of porous hydroxyapatite scaffolds with a functionally graded core/shell structure

Young Mi Soon, Kwan Ha Shin, Young Hag Koh, Jong Hoon Lee, Won Young Choi, Hyoun Ee Kim

School of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

A novel type of porous hydroxyapatite (HA) scaffolds with a functionally graded core/shell structure was fabricated by freeze casting HA/camphene slurries with various HA contents into fugitive molds containing a graphite template with three-dimensionally interconnected pores for the creation of a highly porous core. All the fabricated samples had functionally graded core/shell structures with 3-D periodic pore networks in a core surrounded by a relatively dense shell. The overall porosity of the sample decreased from 60 to 38. vol% with increasing HA content in the HA/camphene slurry from 20 to 36. vol% due to a decrease in porosity in both the core and shell regions. In addition, the compressive strength was improved remarkably from 12 ± 1.1 to 32 ± 3.0 MPa. The in vitro cell test using a pre-osteoblast cell line showed that the samples had good biocompatibility.

Original language	English
Pages (from-to)	13-18
Number of pages	6
Journal	Journal of the European Ceramic Society
Volume	31
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jeurceramsoc.2010.09.008
Publication status	Published - 2011 Jan

Keywords

Apatite
Biomedical applications
Mechanical properties
Porosity
Suspensions

ASJC Scopus subject areas

Ceramics and Composites
Materials Chemistry

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10.1016/j.jeurceramsoc.2010.09.008

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title = "Fabrication and compressive strength of porous hydroxyapatite scaffolds with a functionally graded core/shell structure",

abstract = "A novel type of porous hydroxyapatite (HA) scaffolds with a functionally graded core/shell structure was fabricated by freeze casting HA/camphene slurries with various HA contents into fugitive molds containing a graphite template with three-dimensionally interconnected pores for the creation of a highly porous core. All the fabricated samples had functionally graded core/shell structures with 3-D periodic pore networks in a core surrounded by a relatively dense shell. The overall porosity of the sample decreased from 60 to 38. vol% with increasing HA content in the HA/camphene slurry from 20 to 36. vol% due to a decrease in porosity in both the core and shell regions. In addition, the compressive strength was improved remarkably from 12 ± 1.1 to 32 ± 3.0 MPa. The in vitro cell test using a pre-osteoblast cell line showed that the samples had good biocompatibility.",

keywords = "Apatite, Biomedical applications, Mechanical properties, Porosity, Suspensions",

author = "Soon, {Young Mi} and Shin, {Kwan Ha} and Koh, {Young Hag} and Lee, {Jong Hoon} and Choi, {Won Young} and Kim, {Hyoun Ee}",

note = "Funding Information: This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MEST) (No. 2009-0073415 ).",

year = "2011",

month = jan,

doi = "10.1016/j.jeurceramsoc.2010.09.008",

language = "English",

volume = "31",

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journal = "Journal of the European Ceramic Society",

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AU - Soon, Young Mi

AU - Shin, Kwan Ha

AU - Koh, Young Hag

AU - Lee, Jong Hoon

AU - Choi, Won Young

AU - Kim, Hyoun Ee

N1 - Funding Information: This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MEST) (No. 2009-0073415 ).

PY - 2011/1

Y1 - 2011/1

N2 - A novel type of porous hydroxyapatite (HA) scaffolds with a functionally graded core/shell structure was fabricated by freeze casting HA/camphene slurries with various HA contents into fugitive molds containing a graphite template with three-dimensionally interconnected pores for the creation of a highly porous core. All the fabricated samples had functionally graded core/shell structures with 3-D periodic pore networks in a core surrounded by a relatively dense shell. The overall porosity of the sample decreased from 60 to 38. vol% with increasing HA content in the HA/camphene slurry from 20 to 36. vol% due to a decrease in porosity in both the core and shell regions. In addition, the compressive strength was improved remarkably from 12 ± 1.1 to 32 ± 3.0 MPa. The in vitro cell test using a pre-osteoblast cell line showed that the samples had good biocompatibility.

AB - A novel type of porous hydroxyapatite (HA) scaffolds with a functionally graded core/shell structure was fabricated by freeze casting HA/camphene slurries with various HA contents into fugitive molds containing a graphite template with three-dimensionally interconnected pores for the creation of a highly porous core. All the fabricated samples had functionally graded core/shell structures with 3-D periodic pore networks in a core surrounded by a relatively dense shell. The overall porosity of the sample decreased from 60 to 38. vol% with increasing HA content in the HA/camphene slurry from 20 to 36. vol% due to a decrease in porosity in both the core and shell regions. In addition, the compressive strength was improved remarkably from 12 ± 1.1 to 32 ± 3.0 MPa. The in vitro cell test using a pre-osteoblast cell line showed that the samples had good biocompatibility.

KW - Apatite

KW - Biomedical applications

KW - Mechanical properties

KW - Porosity

KW - Suspensions

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VL - 31

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JO - Journal of the European Ceramic Society

JF - Journal of the European Ceramic Society

IS - 1-2

ER -

Fabrication and compressive strength of porous hydroxyapatite scaffolds with a functionally graded core/shell structure

Abstract

Keywords

ASJC Scopus subject areas

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