Fabrication and compressive strength of porous hydroxyapatite scaffolds with a functionally graded core/shell structure

Young Mi Soon, Kwan Ha Shin, Young-Hag Koh, Jong Hoon Lee, Won Young Choi, Hyoun Ee Kim

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

A novel type of porous hydroxyapatite (HA) scaffolds with a functionally graded core/shell structure was fabricated by freeze casting HA/camphene slurries with various HA contents into fugitive molds containing a graphite template with three-dimensionally interconnected pores for the creation of a highly porous core. All the fabricated samples had functionally graded core/shell structures with 3-D periodic pore networks in a core surrounded by a relatively dense shell. The overall porosity of the sample decreased from 60 to 38. vol% with increasing HA content in the HA/camphene slurry from 20 to 36. vol% due to a decrease in porosity in both the core and shell regions. In addition, the compressive strength was improved remarkably from 12 ± 1.1 to 32 ± 3.0 MPa. The in vitro cell test using a pre-osteoblast cell line showed that the samples had good biocompatibility.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalJournal of the European Ceramic Society
Volume31
Issue number1-2
DOIs
Publication statusPublished - 2011 Jan 1

Fingerprint

Durapatite
Hydroxyapatite
Scaffolds
Compressive strength
Fabrication
Camphene
Porosity
Graphite
Osteoblasts
Slurries
Molds
Biocompatibility
Casting
Cells
camphene

Keywords

  • Apatite
  • Biomedical applications
  • Mechanical properties
  • Porosity
  • Suspensions

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

Cite this

Fabrication and compressive strength of porous hydroxyapatite scaffolds with a functionally graded core/shell structure. / Soon, Young Mi; Shin, Kwan Ha; Koh, Young-Hag; Lee, Jong Hoon; Choi, Won Young; Kim, Hyoun Ee.

In: Journal of the European Ceramic Society, Vol. 31, No. 1-2, 01.01.2011, p. 13-18.

Research output: Contribution to journalArticle

Soon, Young Mi ; Shin, Kwan Ha ; Koh, Young-Hag ; Lee, Jong Hoon ; Choi, Won Young ; Kim, Hyoun Ee. / Fabrication and compressive strength of porous hydroxyapatite scaffolds with a functionally graded core/shell structure. In: Journal of the European Ceramic Society. 2011 ; Vol. 31, No. 1-2. pp. 13-18.
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