Abstract
In this paper, we propose a new fabrication method of pH-responsive microfluidic valves and suggest the feasibility as a microminiature systems without peripheral devices. Conventionally, in-situ photopolymerization method has been employed to build the micro functional structure inside microfluidic channel. Here, we suggest a new method allowing the mass production of stimuli-responsive microsystem through the use of pre-made microstructure as actuating element like assembly of commercial products in the factory. We have massively fabricated pH-responsive microspheres that act as actuating component through the use of PDMSbased microfluidic apparatus and ‘on the fly’ photopolymerization method. By the incorporation of this microsphere into the microvalve during the fabrication process, we have produced the pH-responsive microfluidic valve in a simple way. The operation and the function of the fabricated microvalve were evaluated through the diverse experiments. The microvalve was successfully fabricated, and functioned well according to the pH change.
| Original language | English |
|---|---|
| Pages (from-to) | 294-297 |
| Number of pages | 4 |
| Journal | Unknown Journal |
| Volume | 14 |
| Issue number | 1 |
| Publication status | Published - 2007 |
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Keywords
- Drug delivery
- Microfluidic
- Microsphere
- Microvalve
- pH-responsive
ASJC Scopus subject areas
- Biomedical Engineering
- Bioengineering
Cite this
Fabrication and evaluation of polymeric microvalve using the pH-responsive hydrogel microsphere. / Park, Ji Young; Kim, D. J.; Kim, S. R.; Baek, J. Y.; Sun, Kyung; Lee, Sang Hoon.
In: Unknown Journal, Vol. 14, No. 1, 2007, p. 294-297.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fabrication and evaluation of polymeric microvalve using the pH-responsive hydrogel microsphere
AU - Park, Ji Young
AU - Kim, D. J.
AU - Kim, S. R.
AU - Baek, J. Y.
AU - Sun, Kyung
AU - Lee, Sang Hoon
PY - 2007
Y1 - 2007
N2 - In this paper, we propose a new fabrication method of pH-responsive microfluidic valves and suggest the feasibility as a microminiature systems without peripheral devices. Conventionally, in-situ photopolymerization method has been employed to build the micro functional structure inside microfluidic channel. Here, we suggest a new method allowing the mass production of stimuli-responsive microsystem through the use of pre-made microstructure as actuating element like assembly of commercial products in the factory. We have massively fabricated pH-responsive microspheres that act as actuating component through the use of PDMSbased microfluidic apparatus and ‘on the fly’ photopolymerization method. By the incorporation of this microsphere into the microvalve during the fabrication process, we have produced the pH-responsive microfluidic valve in a simple way. The operation and the function of the fabricated microvalve were evaluated through the diverse experiments. The microvalve was successfully fabricated, and functioned well according to the pH change.
AB - In this paper, we propose a new fabrication method of pH-responsive microfluidic valves and suggest the feasibility as a microminiature systems without peripheral devices. Conventionally, in-situ photopolymerization method has been employed to build the micro functional structure inside microfluidic channel. Here, we suggest a new method allowing the mass production of stimuli-responsive microsystem through the use of pre-made microstructure as actuating element like assembly of commercial products in the factory. We have massively fabricated pH-responsive microspheres that act as actuating component through the use of PDMSbased microfluidic apparatus and ‘on the fly’ photopolymerization method. By the incorporation of this microsphere into the microvalve during the fabrication process, we have produced the pH-responsive microfluidic valve in a simple way. The operation and the function of the fabricated microvalve were evaluated through the diverse experiments. The microvalve was successfully fabricated, and functioned well according to the pH change.
KW - Drug delivery
KW - Microfluidic
KW - Microsphere
KW - Microvalve
KW - pH-responsive
UR - http://www.scopus.com/inward/record.url?scp=84903382092&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903382092&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84903382092
VL - 14
SP - 294
EP - 297
JO - The BMJ
JF - The BMJ
SN - 0730-6512
IS - 1
ER -