Fabrication of 3D curved microstructures using thin PDMS membranes and motion tendency of cells

Dae Ho Lee, Joong Yull Park, Eun Joong Lee, Chang Beom Kim, Sang Hoon Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we report a novel method for the microfabrication of arrays of concave and convex chambers with different diameters and curvatures. We used these structures to study the behavior of cultured mouse fibroblasts and human mesenchymal stem cells, and revealed important cellular behaviors of them. Therefore, our physiological studies indicate that the cultured fibroblast cells and human mesenchymal stem cells can sense micro-scale curvatures and actively respond by "escaping" from concave microwells.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1153-1155
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009 Jan 1
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 2009 Nov 12009 Nov 5

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of
CityJeju
Period09/11/109/11/5

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ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Lee, D. H., Park, J. Y., Lee, E. J., Kim, C. B., & Lee, S. H. (2009). Fabrication of 3D curved microstructures using thin PDMS membranes and motion tendency of cells. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1153-1155). Chemical and Biological Microsystems Society.