Abstract
Hydroxyapatite (HA)/poly(ε-caprolactone) (PCL) composite scaffolds were fabricated using a combination of the extrusion and bi-axial lamination processes. Firstly, HA/PCL composites with various HA contents (0, 50, 60, 70 wt%) were prepared by mixing the HA powders and the molten PCL at 100°C and then extruded through an orifice with dimensions of 600 × 600 μm to produce HA/PCL composite fibers. Isobutyl methacrylate (IBMA) polymer fiber was also prepared in a similar manner for use as a fugitive material. The 3-D scaffold was then produced by the bi-axial lamination of the HA/PCL and IBMA fibers, followed by solvent leaching to remove the IBMA. It was observed that the HA/PCL composites had a superior elastic modulus and biological properties, as compared to the pure PCL. The fabricated HA/PCL scaffold showed a controlled pore structure (porosity of ∼49% and pore size of ∼512 μm) and excellent welding between the HA/PCL fibers, as well as a high compressive strength of ∼7.8 MPa.
| Original language | English |
|---|---|
| Pages (from-to) | 1017-1023 |
| Number of pages | 7 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume | 18 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2007 Jun 1 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biophysics
- Chemical Engineering(all)
- Bioengineering
Cite this
Fabrication of hydroxyapatite-poly(ε-caprolactone) scaffolds by a combination of the extrusion and bi-axial lamination processes. / Sun, Jong J.; Bae, Chang J.; Koh, Young-Hag; Kim, Hyoun E.; Kim, Hae W.
In: Journal of Materials Science: Materials in Medicine, Vol. 18, No. 6, 01.06.2007, p. 1017-1023.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fabrication of hydroxyapatite-poly(ε-caprolactone) scaffolds by a combination of the extrusion and bi-axial lamination processes
AU - Sun, Jong J.
AU - Bae, Chang J.
AU - Koh, Young-Hag
AU - Kim, Hyoun E.
AU - Kim, Hae W.
PY - 2007/6/1
Y1 - 2007/6/1
N2 - Hydroxyapatite (HA)/poly(ε-caprolactone) (PCL) composite scaffolds were fabricated using a combination of the extrusion and bi-axial lamination processes. Firstly, HA/PCL composites with various HA contents (0, 50, 60, 70 wt%) were prepared by mixing the HA powders and the molten PCL at 100°C and then extruded through an orifice with dimensions of 600 × 600 μm to produce HA/PCL composite fibers. Isobutyl methacrylate (IBMA) polymer fiber was also prepared in a similar manner for use as a fugitive material. The 3-D scaffold was then produced by the bi-axial lamination of the HA/PCL and IBMA fibers, followed by solvent leaching to remove the IBMA. It was observed that the HA/PCL composites had a superior elastic modulus and biological properties, as compared to the pure PCL. The fabricated HA/PCL scaffold showed a controlled pore structure (porosity of ∼49% and pore size of ∼512 μm) and excellent welding between the HA/PCL fibers, as well as a high compressive strength of ∼7.8 MPa.
AB - Hydroxyapatite (HA)/poly(ε-caprolactone) (PCL) composite scaffolds were fabricated using a combination of the extrusion and bi-axial lamination processes. Firstly, HA/PCL composites with various HA contents (0, 50, 60, 70 wt%) were prepared by mixing the HA powders and the molten PCL at 100°C and then extruded through an orifice with dimensions of 600 × 600 μm to produce HA/PCL composite fibers. Isobutyl methacrylate (IBMA) polymer fiber was also prepared in a similar manner for use as a fugitive material. The 3-D scaffold was then produced by the bi-axial lamination of the HA/PCL and IBMA fibers, followed by solvent leaching to remove the IBMA. It was observed that the HA/PCL composites had a superior elastic modulus and biological properties, as compared to the pure PCL. The fabricated HA/PCL scaffold showed a controlled pore structure (porosity of ∼49% and pore size of ∼512 μm) and excellent welding between the HA/PCL fibers, as well as a high compressive strength of ∼7.8 MPa.
UR - http://www.scopus.com/inward/record.url?scp=34249078588&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249078588&partnerID=8YFLogxK
U2 - 10.1007/s10856-007-0155-9
DO - 10.1007/s10856-007-0155-9
M3 - Article
C2 - 17242998
AN - SCOPUS:34249078588
VL - 18
SP - 1017
EP - 1023
JO - Journal of Materials Science: Materials in Electronics
JF - Journal of Materials Science: Materials in Electronics
SN - 0957-4522
IS - 6
ER -