Fabrication of hydroxyapatite-poly(ε-caprolactone) scaffolds by a combination of the extrusion and bi-axial lamination processes

Jong J. Sun, Chang J. Bae, Young-Hag Koh, Hyoun E. Kim, Hae W. Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Hydroxyapatite (HA)/poly(ε-caprolactone) (PCL) composite scaffolds were fabricated using a combination of the extrusion and bi-axial lamination processes. Firstly, HA/PCL composites with various HA contents (0, 50, 60, 70 wt%) were prepared by mixing the HA powders and the molten PCL at 100°C and then extruded through an orifice with dimensions of 600 × 600 μm to produce HA/PCL composite fibers. Isobutyl methacrylate (IBMA) polymer fiber was also prepared in a similar manner for use as a fugitive material. The 3-D scaffold was then produced by the bi-axial lamination of the HA/PCL and IBMA fibers, followed by solvent leaching to remove the IBMA. It was observed that the HA/PCL composites had a superior elastic modulus and biological properties, as compared to the pure PCL. The fabricated HA/PCL scaffold showed a controlled pore structure (porosity of ∼49% and pore size of ∼512 μm) and excellent welding between the HA/PCL fibers, as well as a high compressive strength of ∼7.8 MPa.

Original languageEnglish
Pages (from-to)1017-1023
Number of pages7
JournalJournal of Materials Science: Materials in Medicine
Volume18
Issue number6
DOIs
Publication statusPublished - 2007 Jun 1
Externally publishedYes

Fingerprint

Durapatite
Hydroxyapatite
Scaffolds
laminates
Extrusion
porosity
Fabrication
fabrication
composite materials
fibers
Methacrylates
compressive strength
fiber composites
orifices
leaching
welding
modulus of elasticity
Fibers
Composite materials
polymers

ASJC Scopus subject areas

  • Biophysics
  • Chemical Engineering(all)
  • Bioengineering

Cite this

Fabrication of hydroxyapatite-poly(ε-caprolactone) scaffolds by a combination of the extrusion and bi-axial lamination processes. / Sun, Jong J.; Bae, Chang J.; Koh, Young-Hag; Kim, Hyoun E.; Kim, Hae W.

In: Journal of Materials Science: Materials in Medicine, Vol. 18, No. 6, 01.06.2007, p. 1017-1023.

Research output: Contribution to journalArticle

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