Fabrication of mechanically tunable and bioactive metal scaffolds for biomedical applications

Hyun Do Jung, Hyun Lee, Hyoun Ee Kim, Young-Hag Koh, Juha Song

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Biometal systems have been widely used for biomedical applications, in particular, as load-bearing materials. However, major challenges are high stiffness and low bioactivity of metals. In this study, we have developed a new method towards fabricating a new type of bioactive and mechanically reliable porous metal scaffolds-densified porous Ti scaffolds. The method consists of two fabrication processes, 1) the fabrication of porous Ti scaffolds by dynamic freeze casting, and 2) coating and densification of the porous scaffolds. The dynamic freeze casting method to fabricate porous Ti scaffolds allowed the densification of porous scaffolds by minimizing the chemical contamination and structural defects. The densification process is distinctive for three reasons. First, the densification process is simple, because it requires a control of only one parameter (degree of densification). Second, it is effective, as it achieves mechanical enhancement and sustainable release of biomolecules from porous scaffolds. Third, it has broad applications, as it is also applicable to the fabrication of functionally graded porous scaffolds by spatially varied strain during densification.

Original languageEnglish
Article numbere53279
JournalJournal of Visualized Experiments
Volume2015
Issue number106
DOIs
Publication statusPublished - 2015 Dec 8

Fingerprint

Scaffolds
Densification
Metals
Fabrication
Weight-Bearing
Trace Elements
Casting
Bearings (structural)
Chemical contamination
Biomolecules
Scaffolds (biology)
Bioactivity
Stiffness
Coatings
Defects

Keywords

  • Bioengineering
  • Freeze casting
  • Functionally graded materials
  • Hard tissue engineering
  • Issue 106
  • Porous metal scaffold
  • Sustainable drug release
  • Titanium

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemical Engineering(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

Cite this

Fabrication of mechanically tunable and bioactive metal scaffolds for biomedical applications. / Jung, Hyun Do; Lee, Hyun; Kim, Hyoun Ee; Koh, Young-Hag; Song, Juha.

In: Journal of Visualized Experiments, Vol. 2015, No. 106, e53279, 08.12.2015.

Research output: Contribution to journalArticle

@article{648dd2cd96bb4947b72ce9b5ed7a4a4a,
title = "Fabrication of mechanically tunable and bioactive metal scaffolds for biomedical applications",
abstract = "Biometal systems have been widely used for biomedical applications, in particular, as load-bearing materials. However, major challenges are high stiffness and low bioactivity of metals. In this study, we have developed a new method towards fabricating a new type of bioactive and mechanically reliable porous metal scaffolds-densified porous Ti scaffolds. The method consists of two fabrication processes, 1) the fabrication of porous Ti scaffolds by dynamic freeze casting, and 2) coating and densification of the porous scaffolds. The dynamic freeze casting method to fabricate porous Ti scaffolds allowed the densification of porous scaffolds by minimizing the chemical contamination and structural defects. The densification process is distinctive for three reasons. First, the densification process is simple, because it requires a control of only one parameter (degree of densification). Second, it is effective, as it achieves mechanical enhancement and sustainable release of biomolecules from porous scaffolds. Third, it has broad applications, as it is also applicable to the fabrication of functionally graded porous scaffolds by spatially varied strain during densification.",
keywords = "Bioengineering, Freeze casting, Functionally graded materials, Hard tissue engineering, Issue 106, Porous metal scaffold, Sustainable drug release, Titanium",
author = "Jung, {Hyun Do} and Hyun Lee and Kim, {Hyoun Ee} and Young-Hag Koh and Juha Song",
year = "2015",
month = "12",
day = "8",
doi = "10.3791/53279",
language = "English",
volume = "2015",
journal = "Journal of Visualized Experiments",
issn = "1940-087X",
publisher = "MYJoVE Corporation",
number = "106",

}

TY - JOUR

T1 - Fabrication of mechanically tunable and bioactive metal scaffolds for biomedical applications

AU - Jung, Hyun Do

AU - Lee, Hyun

AU - Kim, Hyoun Ee

AU - Koh, Young-Hag

AU - Song, Juha

PY - 2015/12/8

Y1 - 2015/12/8

N2 - Biometal systems have been widely used for biomedical applications, in particular, as load-bearing materials. However, major challenges are high stiffness and low bioactivity of metals. In this study, we have developed a new method towards fabricating a new type of bioactive and mechanically reliable porous metal scaffolds-densified porous Ti scaffolds. The method consists of two fabrication processes, 1) the fabrication of porous Ti scaffolds by dynamic freeze casting, and 2) coating and densification of the porous scaffolds. The dynamic freeze casting method to fabricate porous Ti scaffolds allowed the densification of porous scaffolds by minimizing the chemical contamination and structural defects. The densification process is distinctive for three reasons. First, the densification process is simple, because it requires a control of only one parameter (degree of densification). Second, it is effective, as it achieves mechanical enhancement and sustainable release of biomolecules from porous scaffolds. Third, it has broad applications, as it is also applicable to the fabrication of functionally graded porous scaffolds by spatially varied strain during densification.

AB - Biometal systems have been widely used for biomedical applications, in particular, as load-bearing materials. However, major challenges are high stiffness and low bioactivity of metals. In this study, we have developed a new method towards fabricating a new type of bioactive and mechanically reliable porous metal scaffolds-densified porous Ti scaffolds. The method consists of two fabrication processes, 1) the fabrication of porous Ti scaffolds by dynamic freeze casting, and 2) coating and densification of the porous scaffolds. The dynamic freeze casting method to fabricate porous Ti scaffolds allowed the densification of porous scaffolds by minimizing the chemical contamination and structural defects. The densification process is distinctive for three reasons. First, the densification process is simple, because it requires a control of only one parameter (degree of densification). Second, it is effective, as it achieves mechanical enhancement and sustainable release of biomolecules from porous scaffolds. Third, it has broad applications, as it is also applicable to the fabrication of functionally graded porous scaffolds by spatially varied strain during densification.

KW - Bioengineering

KW - Freeze casting

KW - Functionally graded materials

KW - Hard tissue engineering

KW - Issue 106

KW - Porous metal scaffold

KW - Sustainable drug release

KW - Titanium

UR - http://www.scopus.com/inward/record.url?scp=84952802050&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84952802050&partnerID=8YFLogxK

U2 - 10.3791/53279

DO - 10.3791/53279

M3 - Article

VL - 2015

JO - Journal of Visualized Experiments

JF - Journal of Visualized Experiments

SN - 1940-087X

IS - 106

M1 - e53279

ER -