Fabrication of mechanically tunable and bioactive metal scaffolds for biomedical applications

Hyun Do Jung, Hyun Lee, Hyoun Ee Kim, Young-Hag Koh, Juha Song

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Biometal systems have been widely used for biomedical applications, in particular, as load-bearing materials. However, major challenges are high stiffness and low bioactivity of metals. In this study, we have developed a new method towards fabricating a new type of bioactive and mechanically reliable porous metal scaffolds-densified porous Ti scaffolds. The method consists of two fabrication processes, 1) the fabrication of porous Ti scaffolds by dynamic freeze casting, and 2) coating and densification of the porous scaffolds. The dynamic freeze casting method to fabricate porous Ti scaffolds allowed the densification of porous scaffolds by minimizing the chemical contamination and structural defects. The densification process is distinctive for three reasons. First, the densification process is simple, because it requires a control of only one parameter (degree of densification). Second, it is effective, as it achieves mechanical enhancement and sustainable release of biomolecules from porous scaffolds. Third, it has broad applications, as it is also applicable to the fabrication of functionally graded porous scaffolds by spatially varied strain during densification.

Original languageEnglish
Article numbere53279
JournalJournal of Visualized Experiments
Volume2015
Issue number106
DOIs
Publication statusPublished - 2015 Dec 8

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Keywords

  • Bioengineering
  • Freeze casting
  • Functionally graded materials
  • Hard tissue engineering
  • Issue 106
  • Porous metal scaffold
  • Sustainable drug release
  • Titanium

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemical Engineering(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

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