Fabrication of microstamps and patterned cell network

Nakseon Seong, James Jungho Pak, Ju Hee Choi, Dong June Ahn, Seong Min Hwang, Kyoung J. Lee

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Elastomeric stamps with micrometer-sized grids are fabricated for building biological cell networks by design. Polymerized polydimethyl-siloxane (PDMS) stamps are cast in a variety of different molds prepared by micro-electro mechanical systems (MEMS) technology. Micro square-grid patterns of 3-aminopropyl triethoxy silane (APS) are successfully imprinted on glass plates, and patterned networks of cardiac cells are obtained as designed. The resulting cellular networks clearly demonstrate that cell attachment and growth are greatly favored on APS-treated thin tracks. Here, we report the technical details related to the fabrication of microstamps, to the stamping procedure, and to the culture method. The potential applications of patterned cellular networks are also discussed.

Original languageEnglish
Pages (from-to)605-609
Number of pages5
JournalJournal of the Korean Physical Society
Volume40
Issue number4
DOIs
Publication statusPublished - 2002 Apr

Keywords

  • APS
  • PDMS
  • Stamping

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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