Fabrication of porous extracellular matrix scaffolds from human adipose tissue

Ji Suk Choi, Hyun Jin Yang, Beob Soo Kim, Jae Dong Kim, Sang Hoon Lee, Eun Kyu Lee, Kinam Park, Yong Woo Cho, Hee Young Lee

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Adipose tissue is found over the whole body and easily obtained in large quantities with minimal risk by a common surgical operation, liposuction. Although liposuction was originally intended for the removal of undesired adipose tissue, it may provide an ideal material for tissue engineering scaffolds. Here we present novel, porous scaffolds prepared from human adipose tissues. The scaffolds were fabricated in a variety of macroscopic shapes such as round dishes, squares, hollow tubes, and beads. The microscopic inner porous structure was controlled by the freezing temperature, with a decrease in pore size as the freezing temperature decreased. The scaffold prepared from human adipose tissue contains extracellular matrix components including collagen. Preliminary in vitro studies showed that human adipose-derived stem cells attached to a human extracellular matrix scaffold and proliferated. This scaffold based on human adipose tissue holds great promise for many clinical applications in regenerative medicine, particularly in patients requiring soft-tissue regeneration.

Original languageEnglish
Pages (from-to)387-396
Number of pages10
JournalTissue Engineering - Part C: Methods
Volume16
Issue number3
DOIs
Publication statusPublished - 2010 Jun 1

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering

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