Fabrication of three-dimensional microarray structures by controlling the thickness and elasticity of poly (dimethylsiloxane) membrane

Dae Ho Lee, Joong Yull Park, Eun Joong Lee, Yoon Young Choi, Gu Han Kwon, Beop Min Kim, Sang Hoon Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In this paper, we propose a method to construct three-dimensional curved microstructures with easy control of the size, position and shape, by exploiting the elasticity of poly(dimethylsiloxane) (PDMS) membranes and basic physics. For this end, we developed the method to handle thin PDMS membrane safely, and to replicate PDMS microstructure from the PDMS mold. Using this method, we demonstrated two potential applications: (1) the use of concave well for the formation of embryoid body (EB) to differentiate into neuronal cells, and (2) the fabrication of SU-8 and hydrogel microparticles having diverse curved shapes. The curved structures were successfully fabricated with simple process, and EBs were formed in the concave well and differentiated into the neuronal cells. Microparticles with diverse shapes were fabricated from a range of materials for potential use as drug carrier and pH responsive micro-actuator elements.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalBiomedical Microdevices
Volume12
Issue number1
DOIs
Publication statusPublished - 2010 Feb 1

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Keywords

  • Curved microstructure
  • Elasticity of PDMS
  • Embryoid body
  • PDMS membrane

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

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