Several fabrication methods are used to prepare the components of self-healing nanotextured vascular materials. These include the general method of electrospinning discussed in Sect. 4.1 and its variant of co-electrospinning discussed in Sect. 4.2; the latter is used to form core-shell nanofibers (NFs) that contain healing agents in their cores. Another variant of electrospinning used to form such NFs is the emulsion spinning, which is described in Sect. 4.3. Instead of electrospinning, another general method of solution blowing (see Sect. 4.4) can be used to form NFs. This method is industrially scalable, and its variant of coaxial solution blowing can be used to rapidly manufacture core-shell NFs with healing agents in the cores (Sect. 4.5). Another variant of solution blowing—emulsion blowing—has also been used to form core-shell NFs with healing agents in the core (Sect. 4.6). All the abovementioned chapters discuss the fabrication of essentially two-dimensional self-healing materials. The subsequent Sect. 4.7 describes the methods of fabrication of two- and three-dimensional self-healing composites with embedded nanotextured vascular systems based on core-shell NFs.